Literature DB >> 530497

The effect of morphine applied locally to mesencephalic dopamine cell bodies on spontaneous motor activity in the rat.

E M Joyce, S D Iversen.   

Abstract

The effect of local application of morphine (5 microgram) into the ventral tegmental area (VTA) or substantia nigra, pars compacta (SNc) on spontaneous activity was studied in the rat. Morphine in the VTA but not SNc produced an enhancement of locomotor activity which became progressively augmented with repeated injections. This effect could be blocked by systemic injections of naloxone or haloperidol. It is suggested that stimulation of opiate receptors in the vicinity of dopamine cell bodies can increase the activity of ascending mesencephalic dopamine neurones.

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Year:  1979        PMID： 530497     DOI： 10.1016/0304-3940(79)96149-4

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  54 in total

1.  Locomotor-activating effects of the D2 agonist bromocriptine show environment-specific sensitization following repeated injections.

Authors:  D C Hoffman; R A Wise
Journal:  Psychopharmacology (Berl)       Date:  1992       Impact factor: 4.530

Review 2.  Motivational Processes Underlying Substance Abuse Disorder.

Authors:  Paul J Meyer; Christopher P King; Carrie R Ferrario
Journal:  Curr Top Behav Neurosci       Date:  2016

3.  Expression of morphine-conditioned hyperactivity is attenuated by naloxone and pimozide.

Authors:  J L Neisewander; M T Bardo
Journal:  Psychopharmacology (Berl)       Date:  1987       Impact factor: 4.530

4.  Morphine-induced conditioned place preference and effects of morphine pre-exposure in adolescent and adult male C57BL/6J mice.

Authors:  Wouter Koek
Journal:  Psychopharmacology (Berl)       Date:  2014-07-29       Impact factor: 4.530

5.  Withdrawal from repeated morphine sensitizes mice to the striatal dopamine release enhancing effect of acute morphine.

Authors:  J Airio; M Attila; T Leikola-Pelho; L Ahtee
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1994-11       Impact factor: 3.000

6.  Motor stimulant effects of ethanol and acetaldehyde injected into the posterior ventral tegmental area of rats: role of opioid receptors.

Authors:  María José Sánchez-Catalán; Lucía Hipólito; Teodoro Zornoza; Ana Polache; Luis Granero
Journal:  Psychopharmacology (Berl)       Date:  2009-02-24       Impact factor: 4.530

7.  Chronic neuroleptic treatment and mesolimbic dopamine denervation induce behavioural supersensitivity to opiates.

Authors:  L Stinus; M Winnock; A E Kelley
Journal:  Psychopharmacology (Berl)       Date:  1985       Impact factor: 4.530

8.  Supplemental morphine infusion into the posterior ventral tegmentum extends the satiating effects of self-administered intravenous heroin.

Authors:  S Steidl; S Myal; R A Wise
Journal:  Pharmacol Biochem Behav       Date:  2015-04-23       Impact factor: 3.533

9.  Locomotor stimulant effects of acute and repeated intrategmental injections of salsolinol in rats: role of mu-opioid receptors.

Authors:  Lucía Hipólito; María-José Sánchez-Catalán; Teodoro Zornoza; Ana Polache; Luis Granero
Journal:  Psychopharmacology (Berl)       Date:  2010-03       Impact factor: 4.530

10.  Cocaine seeking over extended withdrawal periods in rats: time dependent increases of responding induced by heroin priming over the first 3 months.

Authors:  Lin Lu; Jack Dempsey
Journal:  Psychopharmacology (Berl)       Date:  2004-04-08       Impact factor: 4.530
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