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Literature DB >> 5297527

The effect of 5-hydroxytryptamine on the cotton pellet local inflammatory response in the rat.

Abstract

The cotton pellet technique was used to evaluate the effect of 5-HT and certain related compounds on granuloma formation in the rat. 5-HT (10 mg/kg) significantly decreased granuloma formation, significantly increased adrenal weight, and significantly decreased thymus weight in normal rats, and significantly decreased granuloma formation and thymus weight in sham-operated rats. On the other hand, 5-HT (10 mg/kg) significantly increased granuloma weight in adrenalectomized rats. Methysergide (1 mg/kg) blocked the inhibitory effect of 5-HT on granuloma formation as well as the changes in weight of adrenal and thymus glands. 5-HIAA (11 mg/kg) and 5-HTP (13 mg/kg) failed to alter granuloma formation.

Entities: Chemical Disease Species

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Year: 1967 PMID： 5297527 PMCID： PMC2138287 DOI： 10.1084/jem.125.3.501

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

24 in total

1. MALIGNANT CARCINOID SYNDROME WITH SCLERODERMA.

Authors: D R HAY
Journal: N Z Med J Date: 1964-02

2. EFFECT OF ADRENALECTOMY ON COTTON PELLET GRANULOMA FORMATION IN THE RAT.

Authors: A ASHFORD; G B PENN
Journal: J Pharm Pharmacol Date: 1965-01 Impact factor: 3.765

3. Observations on the pathogenesis of carcinoid hear disease and the tanning of fluorescent fibrin by 5-hydroxytryptamine and ceruloplasmin.

Authors: H R BATES; R F CLARK
Journal: Am J Clin Pathol Date: 1963-01 Impact factor: 2.493

4. Pathogenesis of lesions induced by serotonin: nutritional, vascular, autoradiographic, and comparative studies using epinephrine.

Authors: R A MacDONALD
Journal: Am J Pathol Date: 1959 Mar-Apr Impact factor: 4.307

8. Malignant carcinoid of the small intestine with metastases to the liver, valvular disease of the right side of the heart (pulmonary stenosis and tricuspid regurgitation without septal defects), peripheral vasomotor symptoms, bronchoconstriction, and an unusual type of cyanosis; a clinical and pathologic syndrome.

Authors: A THORSON; G BIORCK; G BJORKMAN; J WALDENSTROM
Journal: Am Heart J Date: 1954-06 Impact factor: 4.749

The effect of 5-hydroxytryptamine on the cotton pellet local inflammatory response in the rat.

1. MALIGNANT CARCINOID SYNDROME WITH SCLERODERMA.

2. EFFECT OF ADRENALECTOMY ON COTTON PELLET GRANULOMA FORMATION IN THE RAT.

3. Observations on the pathogenesis of carcinoid hear disease and the tanning of fluorescent fibrin by 5-hydroxytryptamine and ceruloplasmin.

4. Pathogenesis of lesions induced by serotonin: nutritional, vascular, autoradiographic, and comparative studies using epinephrine.

5. Studies on carcinoid disease.

6. Dermal fibrosis following subcutaneous injections of serotonin creatinine sulphate.

7. Association of functioning carcinoid syndrome and scleroderma. I. Case report.

9. [On the mechanism of cortisone inhibition of connective tissue proliferation].

10. THE CARDIAC DISEASE ASSOCIATED WITH THE CARCINOID SYNDROME (CARCINOID HEART DISEASE).

1. Comparative trial of serotonin antagonists in the management of migraine.