| Literature DB >> 5289036 |
P Dukor, C Bianco, V Nussenzweig.
Abstract
To determine the tissue localization of lymphocytes provisionally termed "complement-receptor lymphocytes," which are characterized by having a membrane receptor for antigen-antibody-complement complexes, we investigated the adherence of sensitized and nonsensitized sheep red cells to frozen sections of mouse lymphoid organs. Nonsensitized erythrocytes became bound exclusively to sinus-lining cells of spleen and lymph nodes, whereas erythrocytes sensitized with antibody and complement adhered to lymphocytes in the follicular areas and the marginal zone of the spleen and in the true cortex of lymph nodes. However, the doubly sensitized erythrocytes failed to bind to the "thymus-dependent" areas of peripheral lymphoid organs or to the thymus itself. We suggest that complement-receptor lymphocytes are of extrathymic origin and that they contribute substantially to follicular antigen localization, which appears to be complement-dependent.Entities:
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Year: 1970 PMID： 5289036 PMCID： PMC283303 DOI： 10.1073/pnas.67.2.991
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205