Literature DB >> 5289035

Differentiation of mouse plasmocytomas in vitro: two phenotypically stabilized variants of the same cell.

A Paraf, M A Moyne, J F Duplan, R Scherrer, M Stanislawski, M Bettane, L Lelievre, P Rouze, J M Dubert.   

Abstract

Mouse myelomas from Balb/c and C3H mice were established in tissue culture for more than 200 passages. When allowed to attach to a surface, they differentiated into two stabilized forms, one of which was fibroblast-shaped, grew without contact inhibition, and could be transplanted back to mice. The other had the morphology of epithelial cells, showed contact inhibition, and was not transplantable back to mice. For one strain (MOPC 173) it was demonstrated that both types of cells synthesize molecules with idiotypic determinants of the original myeloma protein. The relationship between the host cells and a leukemia-type virus present in the original tumor cells has been studied during different stages of cellular differentiation.

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Year:  1970        PMID： 5289035      PMCID： PMC283302          DOI： 10.1073/pnas.67.2.983

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  18 in total

1.  Virus-like bodies in a transplantable mouse plasma cell tumour.

Authors:  A F HOWATSON; E A McCULLOCH
Journal:  Nature       Date:  1958-04-26       Impact factor: 49.962

2.  Induction of virus synthesis in polyoma transformed cells by ultraviolet light and mitomycin C.

Authors:  M Fogel; L Sachs
Journal:  Virology       Date:  1970-01       Impact factor: 3.616

3.  Stimulation of cell growth in vitro by serum with and without growth factor. Relation to contact inhibition and viral transformation.

Authors:  J L Jainchill; G J Todaro
Journal:  Exp Cell Res       Date:  1970-01       Impact factor: 3.905

4.  Immunoglobulin assembly in a mouse myeloma.

Authors:  D Schubert
Journal:  Proc Natl Acad Sci U S A       Date:  1968-06       Impact factor: 11.205

5.  The formation of variants with a reversion of properties of transformed cells. I. Variants from polyoma-transformed cells grown in vivo.

Authors:  Z Rabinowitz; L Sachs
Journal:  Virology       Date:  1969-06       Impact factor: 3.616

6.  Immunoglobulin synthesis by cultured mouse myeloma cells.

Authors:  Y Namba; M Hanaoka
Journal:  J Immunol       Date:  1969-06       Impact factor: 5.422

7.  Immunological activity of thymus and thoracic-duct lymphocytes.

Authors:  G F Mitchell; J F Miller
Journal:  Proc Natl Acad Sci U S A       Date:  1968-01       Impact factor: 11.205

8.  Heritability of cellular differentiation: clonal growth and expression of differentiation in retinal pigment cells in vitro.

Authors:  R D Cahn; M B Cahn
Journal:  Proc Natl Acad Sci U S A       Date:  1966-01       Impact factor: 11.205

9.  Ultrastructural localization of antibody in differentiating plasma cells.

Authors:  E H Leduc; S Avrameas; M Bouteille
Journal:  J Exp Med       Date:  1968-01-01       Impact factor: 14.307

10.  Antibody formation in vitro.

Authors:  M FISHMAN
Journal:  J Exp Med       Date:  1961-12-01       Impact factor: 14.307
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  2 in total

1.  Some structural and antigenic properties of intracisternal A particles occurring in mouse tumors (complement fixation-immunodiffusion-neuroblastoma-plasma-cell tumor).

Authors:  E L Kuff; K K Leuders; H L Ozer; N A Wivel
Journal:  Proc Natl Acad Sci U S A       Date:  1972-01       Impact factor: 11.205

2.  Long-term establishment of a human plasmacyte cell line derived from a patient with IgD multiple myeloma. I. Requirement of a plasmacyte-stimulating factor for the proliferation of myeloma cells in tissue culture.

Authors:  M E Jobin; J L Fahey; Z Price
Journal:  J Exp Med       Date:  1974-08-01       Impact factor: 14.307
  2 in total

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