Literature DB >> 5288758

X-irradiation enhancement of transformation by benzo(a)pyrene in hamster embryo cells.

J A DiPaolo, P J Donovan, R L Nelson.   

Abstract

The addition of benzo(a)pyrene to cells obtained from Syrian hamster embryo cultures that had been plated to produce discrete colonies resulted in transformation. Altered colonies were not seen in controls. Prior irradiation of hamster embryo cells increased the transformation by benzo(a)pyrene, both per cell and per total colony. Maximum enhancement occurred when benzo(a)pyrene was added 48 hr after irradiation. Enhancement was greatest after 250-500 R, and decreased with higher doses of radiation. The addition of benzo(a)pyrene 72 hr after irradiation resulted in very little enhancement. Although transformation increased with benzo(a)pyrene concentration, enhancement was independent of concentration within the range used. No colony with transformed morphology was recognized among the colonies of normal cells that survived irradiation.

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Year:  1971        PMID： 5288758      PMCID： PMC389282          DOI： 10.1073/pnas.68.8.1734

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  9 in total

1.  EFFECT OF X-IRRADIATION ON SUSCEPTIBILITY OF CELLS TO TRANSFORMATION BY POLYOMA VIRUS.

Authors:  M STOKER
Journal:  Nature       Date:  1963-11-23       Impact factor: 49.962

2.  Radiation enhancement of SV40 transformation in 3T3 and human cells.

Authors:  E J Pollock; G J Todaro
Journal:  Nature       Date:  1968-08-03       Impact factor: 49.962

3.  Quantitative studies of in vitro transformation by chemical carcinogens.

Authors:  J A DiPaolo; P Donovan; R Nelson
Journal:  J Natl Cancer Inst       Date:  1969-05       Impact factor: 13.506

4.  The binding of 7,12-dimethylbenz(A)anthracene to replicating and non-replicating DNA in cell culture.

Authors:  S H Yuspa; S del A Eaton; D L Morgan; R R Bates
Journal:  Chem Biol Interact       Date:  1969-12       Impact factor: 5.192

5.  In vitro transformation of hamster cells by polycyclic hydrocarbons: factors influencing the number of cells transformed.

Authors:  J A DiPaolo; P J Donovan; R L Nelson
Journal:  Nat New Biol       Date:  1971-04-21

6.  Cell susceptibility to transformation and cytotoxicity by the carcinogenic hydrocarbon benzo[a]pyrene.

Authors:  E Huberman; L Sachs
Journal:  Proc Natl Acad Sci U S A       Date:  1966-10       Impact factor: 11.205

7.  In vitro cell transformation by x-irradiation.

Authors:  C Borek; L Sachs
Journal:  Nature       Date:  1966-04-16       Impact factor: 49.962

8.  Radioautographic analysis of 7,12-dimethyl-benz(a)anthracene-3H incorporation and cell survival of Syrian hamster embryo cells during exposure to nucleic acid inhibitors.

Authors:  D I Connell; L A Riechers; J A DiPaolo
Journal:  J Natl Cancer Inst       Date:  1971-01       Impact factor: 13.506

9.  Enhanced virus transformation of hamster embryo cells in vitro.

Authors:  J H Coggin
Journal:  J Virol       Date:  1969-05       Impact factor: 5.103
  9 in total
  4 in total

1.  The effect of X-irradiation on hydrocarbon metabolism and on hydrocarbon-induced lethality and transformation in cells derived from mouse prostate.

Authors:  H Marquardt
Journal:  Z Krebsforsch Klin Onkol Cancer Res Clin Oncol       Date:  1973-12-06

2.  A general theory of carcinogenesis.

Authors:  D E Comings
Journal:  Proc Natl Acad Sci U S A       Date:  1973-12       Impact factor: 11.205

3.  The histological appearance of tumours derived from rat embryo cells transformed in vitro spontaneously and after treatment with nitrosomethylurea.

Authors:  D J Kirkland; C R Pick
Journal:  Br J Cancer       Date:  1973-11       Impact factor: 7.640

4.  Two-stage carcinogenesis with rat embryo cells in tissue culture.

Authors:  C Lasne; A Gentil; I Chouroulinkov
Journal:  Br J Cancer       Date:  1977-06       Impact factor: 7.640
  4 in total

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