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Literature DB >> 528777

Influence of bromocriptine on plasma levels of prolactin and steroid hormones in the 20th week of pregnancy.

Abstract

The influence of bromocriptine, a prolactin antagonist, on maternal plasma and amniotic fluid prolactin (PRL) was investigated in two pregnancies at the 20th week with medical indication for abortion. Voluntary consensus of the patients was obtained. Blood sample determinations demonstrated that bromocriptine inhibits the secretion of PRL both in plasma and amniotic fluid. Since no changes were observed in peripheral maternal steroid concentrations of dehydroepiandrosterone, dehydroepiandrosterone-sulfate, delta 4-androstene-3, 17-dione, testosterone, estradiol, estriol, and cortisol, it is concluded that PRL does not seem to affect maternal and fetal adrenal cortex as supposed in amenorrhoic patients with hyperprolactinemia.

Entities: Chemical Disease Gene Species

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Year: 1979 PMID： 528777 DOI： 10.1007/BF03350411

Source DB: PubMed Journal: J Endocrinol Invest ISSN： 0391-4097 Impact factor: 4.256

13 in total

1. The ontogenesis of human fetal hormones. III. Prolactin.

Authors: M J Aubert; M M Grumbach; S L Kaplan
Journal: J Clin Invest Date: 1975-07 Impact factor: 14.808

2. Endocrine studies in anencephaly.

Authors: A Hayek; S G Driscoll; J B Warshaw
Journal: J Clin Invest Date: 1973-07 Impact factor: 14.808

3. Sources and disposition of pituitary prolactin in maternal circulation, amniotic fluid, fetus and placenta in the pregnant rhesus monkey.

Authors: J B Josimovich; G Weiss; D L Hutchinson
Journal: Endocrinology Date: 1974-05 Impact factor: 4.736

4. HCG + ACTH stimulation of in vitro dehydroepiandrosterone production in human fetal adrenals from precursor cholesterol and delta5-pregnenolone.

Authors: W D Lehmann; C Lauritzen
Journal: J Perinat Med Date: 1975 Impact factor: 1.901

Influence of bromocriptine on plasma levels of prolactin and steroid hormones in the 20th week of pregnancy.

1. The ontogenesis of human fetal hormones. III. Prolactin.

2. Endocrine studies in anencephaly.

3. Sources and disposition of pituitary prolactin in maternal circulation, amniotic fluid, fetus and placenta in the pregnant rhesus monkey.

4. HCG + ACTH stimulation of in vitro dehydroepiandrosterone production in human fetal adrenals from precursor cholesterol and delta5-pregnenolone.

5. Study on maternal, fetal, and amniotic human prolactin at term.

Review 6. Hypothesis: placental membranes produce prolactin.

7. Radioligand assay for 5 -3 -hydroxysteroids. I. 3 -Hydroxy-5-androstene-17-one and its 3-sulfate.

8. Effect of prolactin on plasma DHEA (s) levels.

9. A radioimmunoassay for human prolactin.

10. Plasma androgens in women with hyperprolactinaemic amenorrhoea.

Review 1. Prolactinoma through the female life cycle.

2. Maternal serum hormone changes during abortion induced with 9-deoxo-16, 16-dimethyl-9-methylene prostaglandin E2.

3. Effect of metoclopramide on maternal and fetal hyperprolactinemia.