Literature DB >> 528375

Synthesis and antibacterial activity of 1-N-(1,3-dihydroxy-2-propyl)kanamycin B (UK-31,214).

K Richardson, K W Brammer, S Jevons, R M Plews, J R Wright.   

Abstract

1-N-(1,3-Dihydroxy-2-propyl)kanamycin B was prepared and its in vitro activity against aminoglycoside-sensitive and aminoglycoside-resistant organisms was compared with that of kanamycin B and gentamicin. This kanamycin B derivative (code No. UK-31,214) demonstrated potent activity in all of these tests and gave good protection in experimental infections in mice.

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Year:  1979        PMID: 528375     DOI: 10.7164/antibiotics.32.973

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN: 0021-8820            Impact factor:   2.649


  2 in total

Review 1.  Aminoglycoside research 1975-1985: prospects for development of improved agents.

Authors:  K E Price
Journal:  Antimicrob Agents Chemother       Date:  1986-04       Impact factor: 5.191

2.  UK31214, a new aminoglycoside and derivative of kanamycin B.

Authors:  R Wise; J M Andrews; K A Bedford
Journal:  Antimicrob Agents Chemother       Date:  1980-03       Impact factor: 5.191

  2 in total

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