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Literature DB >> 528373

Tetrahydropyranyl derivatives of daunomycin and adriamycin.

H Umezawa, Y Takahashi, M Kinoshita, H Naganawa, T Masuda, M Ishizuka, K Tatsuta, T Takeuchi.

Abstract

Entities: Chemical

Mesh：

Substances：

Year: 1979 PMID： 528373 DOI： 10.7164/antibiotics.32.1082

Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649

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33 in total

1. Phase I study of pirarubicin.

Authors: A A Miller; M E Scheulen; U R Kleeberg; S Seeber; C G Schmidt
Journal: J Cancer Res Clin Oncol Date: 1988 Impact factor: 4.553

2. (2"-R)-4'-o-tetrahydropyranyladriamycin, a new anthracycline derivative; its effectiveness in lymphoid malignancies.

Authors: T Takagi; M Oguro
Journal: Cancer Chemother Pharmacol Date: 1987 Impact factor: 3.333

3. A phase II study of (2"R)-4'-0-tetrahydropyranyladriamycin (THP) in hematological malignancies.

Authors: K Yamada; S Shirakawa; R Ohno; H Yamada; Y Hirota; K Ohara; K Yamagata; M Kobayashi; M Hirano; Y Ikeda
Journal: Invest New Drugs Date: 1987 Impact factor: 3.850

4. Treatment of acute leukemia and malignant lymphoma with (2"R)-4'-O-tetrahydropyranyladriamycin.

Authors: R Ohno; K Kimura; I Amaki; M Hirano; A Hoshino; Y Ikeda; I Kimura; M Kobayashi; K Konno; H Majima
Journal: Cancer Chemother Pharmacol Date: 1987 Impact factor: 3.333

5. Acute and late toxicities of pirarubicin in the treatment of childhood acute lymphoblastic leukemia: results from a clinical trial by the Japan Association of Childhood Leukemia Study.

Authors: Hiroki Hori; Tooru Kudoh; Shinichiro Nishimura; Megumi Oda; Makoto Yoshida; Junichi Hara; Akio Tawa; Ikuya Usami; Akihiko Tanizawa; Keiko Yumura-Yagi; Koji Kato; Ryoji Kobayashi; Yoshihiro Komada; Keitaro Matsuo; Keizo Horibe
Journal: Int J Clin Oncol Date: 2016-11-17 Impact factor: 3.402

10. Synthesis and DNA-binding affinity studies of glycosylated intercalators designed as functional mimics of the anthracycline antibiotics.

Authors: Wei Shi; Robert S Coleman; Todd L Lowary
Journal: Org Biomol Chem Date: 2009-07-17 Impact factor: 3.876

Tetrahydropyranyl derivatives of daunomycin and adriamycin.

1. Phase I study of pirarubicin.

2. (2"-R)-4'-o-tetrahydropyranyladriamycin, a new anthracycline derivative; its effectiveness in lymphoid malignancies.

3. A phase II study of (2"R)-4'-0-tetrahydropyranyladriamycin (THP) in hematological malignancies.

4. Treatment of acute leukemia and malignant lymphoma with (2"R)-4'-O-tetrahydropyranyladriamycin.

5. Acute and late toxicities of pirarubicin in the treatment of childhood acute lymphoblastic leukemia: results from a clinical trial by the Japan Association of Childhood Leukemia Study.

6. Phase I clinical trial and pharmacokinetic evaluation of 4'-0-tetrahydropyranyladriamycin (THP-adriamycin).

7. Doxorubicin-heparin complex: reduction of cardiotoxicity of doxorubicin.

8. Pharmacokinetics and disposition of 4'-O-tetrahydropyranyladriamycin in mice by HPLC analysis.

9. Phase I clinical trial of a new anthracycline: 4'-o-tetrahydropyranyl adriamycin.

10. Synthesis and DNA-binding affinity studies of glycosylated intercalators designed as functional mimics of the anthracycline antibiotics.