Literature DB >> 528077

Anti-tumor potential of retinoic acid: stimulation of immune mediated effectors.

P Q Patek, J L Collins, G Yogeeswaran, G Dennert.   

Abstract

Data are presented on the effects of retinoic acid (RA) treatment on the in vivo growth of tumors in two mouse strains. Inhibition of tumor growth as a result of systemic RA injection was observed in three out of seven tumor models. Using adult thymectomized, lethally irradiated and fetal liver (A x TFL) reconstituted mice, we found that inhibition of tumor growth is not due to direct toxic effects of RA but rather appears to be the result of stimulation of thymus-dependent immune-mediated effectors to suppress tumor growth. Results suggest that only strongly immunogenic tumors are sensitive to in vivo retinoid inhibition.

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Year:  1979        PMID： 528077     DOI： 10.1002/ijc.2910240516

Source DB:  PubMed          Journal:  Int J Cancer        ISSN： 0020-7136            Impact factor:   7.396


  5 in total

1.  Regulation of accessory cell function by retinoids in murine immune responses.

Authors:  D R Katz; M Drzymala; J A Turton; R M Hicks; R Hunt; L Palmer; M Malkovský
Journal:  Br J Exp Pathol       Date:  1987-06

2.  Maintenance therapy with 13-cis retinoid acid in high-grade glioma at complete response after first-line multimodal therapy--a phase-II study.

Authors:  Caecilia Wismeth; Peter Hau; Klaus Fabel; Ulrike Baumgart; Birgit Hirschmann; Horst Koch; Tanja Jauch; Oliver Grauer; Lisa Drechsel; Alexander Brawanski; Ulrich Bogdahn; Andreas Steinbrecher
Journal:  J Neurooncol       Date:  2004-05       Impact factor: 4.130

3.  Enhancement of specific antitumor immunity in mice fed a diet enriched in vitamin A acetate.

Authors:  M Malkovský; C Doré; R Hunt; L Palmer; P Chandler; P B Medawar
Journal:  Proc Natl Acad Sci U S A       Date:  1983-10       Impact factor: 11.205

4.  Inhibition of growth and spontaneous metastasis of syngeneic transplantable tumors by an aromatic retinoic acid analogue. 1. Relationship between tumour immunogenicity and responsiveness.

Authors:  S A Eccles; S C Barnett; P Alexander
Journal:  Cancer Immunol Immunother       Date:  1985       Impact factor: 6.968

5.  Inhibition of growth and metastasis of syngeneic transplantable tumours by an aromatic retinoic acid analogue. 2. T cell dependence of retinoid effects in vivo.

Authors:  S A Eccles; H P Purvies; S C Barnett; P Alexander
Journal:  Cancer Immunol Immunother       Date:  1985       Impact factor: 6.968
  5 in total

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