Literature DB >> 5277077

Loss of feedback control of hydroxymethylglutaryl coenzyme A reductase in hepatomas.

M D Siperstein, A M Gyde, H P Morris.   

Abstract

THE FEEDBACK RESPONSE OF MEVALONATE: NADP oxidoreductase (acylating CoA; EC 1.1.1.34) in two varieties of hepatoma has been examined. In marked contrast to the feedback inhibition of this enzyme that is regularly observed in normal liver, the feedback control is completely lost in minimal-deviation hepatomas 9121 and 3924A. This finding provides the first specific biochemical localization of the defect in cholesterol feedback control, which has been shown previously to be a characteristic of all hepatomas.

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Year:  1971        PMID： 5277077      PMCID： PMC388926          DOI： 10.1073/pnas.68.2.315

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  15 in total

1.  Rhythmic changes of hydroxymethylglutaryl coenzyme a reductase activity in livers of fed and fasted rats.

Authors:  B Hamprecht; C Nüssler; F Lynen
Journal:  FEBS Lett       Date:  1969-07       Impact factor: 4.124

2.  DELETION OF THE CHOLESTEROL-NEGATIVE FEEDBACK SYSTEM IN LIVER TUMORS.

Authors:  M D SIPERSTEIN; V M FAGAN
Journal:  Cancer Res       Date:  1964-08       Impact factor: 12.701

3.  Lipid metabolism and atherosclerosis.

Authors:  R G GOULD
Journal:  Am J Med       Date:  1951-08       Impact factor: 4.965

4.  The demonstration and solubilization of beta-hydroxy-beta-methylglutaryl coenzyme A reductase from rat liver microsomes.

Authors:  T C Linn
Journal:  J Biol Chem       Date:  1967-03-10       Impact factor: 5.157

5.  Studies on the feed-back regulation of cholesterol synthesis.

Authors:  M D Siperstein; V M Fagan
Journal:  Adv Enzyme Regul       Date:  1964

6.  Regulation of 3-hydroxy-3-methylglutarate and mevalonate biosynthesis by rat liver homogenates. Effects of fasting, cholesterol feeding, and triton administration.

Authors:  L W White; H Rudney
Journal:  Biochemistry       Date:  1970-06-23       Impact factor: 3.162

7.  Biosynthesis of 3-hydroxy-3-methylglutarate and mevalonate by rat liver homogenates in vitro.

Authors:  L W White; H Rudney
Journal:  Biochemistry       Date:  1970-06-23       Impact factor: 3.162

8.  The effect of cholesterol feeding and fasting upon beta-hydroxy-beta-methylglutaryl coenzyme A reductase.

Authors:  T C Linn
Journal:  J Biol Chem       Date:  1967-03-10       Impact factor: 5.157

9.  A gas-liquid chromatographic procedure for the measurement of mevalonic acid synthesis.

Authors:  M D Siperstein; V M Fagan; J M Dietschy
Journal:  J Biol Chem       Date:  1966-02-10       Impact factor: 5.157

10.  Cholesterol biosynthesis in preparations of liver from normal, fasting, x-irradiated, cholesterol-fed, triton, or delta 4-cholesten-3-one-treated rats.

Authors:  N L BUCHER; K McGARRAHAN; E GOULD; A V LOUD
Journal:  J Biol Chem       Date:  1959-02       Impact factor: 5.157
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  12 in total

1.  The relationship of cholesterol biosynthesis to cancer.

Authors:  M D Siperstein
Journal:  Trans Am Clin Climatol Assoc       Date:  1972

2.  A discoordinate increase in the cellular amount of 3-hydroxy-3-methylglutaryl-CoA reductase results in the loss of rate-limiting control over cholesterogenesis in a tumour cell-free system.

Authors:  N I Azrolan; P S Coleman
Journal:  Biochem J       Date:  1989-03-01       Impact factor: 3.857

3.  Effect of lovastatin alone and as an adjuvant chemotherapeutic agent on hepatoma tissue culture-4 cell growth.

Authors:  T J Morris; S L Palm; L L Furcht; H Buchwald
Journal:  Ann Surg Oncol       Date:  1995-05       Impact factor: 5.344

4.  Essential role for mevalonate synthesis in DNA replication.

Authors:  V Quesney-Huneeus; M H Wiley; M D Siperstein
Journal:  Proc Natl Acad Sci U S A       Date:  1979-10       Impact factor: 11.205

5.  Dolichol biosynthesis in human malignant cells.

Authors:  A Henry; P W Stacpoole; C M Allen
Journal:  Biochem J       Date:  1991-09-15       Impact factor: 3.857

6.  Suppression of murine neuroblastoma growth in vivo by mevinolin, a competitive inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

Authors:  W A Maltese; R Defendini; R A Green; K M Sheridan; D K Donley
Journal:  J Clin Invest       Date:  1985-11       Impact factor: 14.808

7.  Studies of the in vivo metabolism of mevalonic acid in the normal rat.

Authors:  K H Hellstrom; M D Siperstein; L A Bricker; L J Luby
Journal:  J Clin Invest       Date:  1973-06       Impact factor: 14.808

8.  Absence of cholesterogenesis regulation in the liver and prostate of the BIO 87.20 hamster.

Authors:  C P Schaffner; D R Brill; A K Singhal; D P Bonner; N I Goldstein; G M Wang
Journal:  Lipids       Date:  1981-11       Impact factor: 1.880

9.  Comparison of regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in hepatoma cells grown in vivo and in vitro.

Authors:  O R Beirne; J A Watson
Journal:  Proc Natl Acad Sci U S A       Date:  1976-08       Impact factor: 11.205

10.  Loss of the cholesterol feedback system in the intact hepatoma-bearing rat.

Authors:  L A Bricker; H P Morris; M D Siperstein
Journal:  J Clin Invest       Date:  1972-02       Impact factor: 14.808
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