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Literature DB >> 5276297

Studies on memory: distribution of peptidyl-puromycin in subcellular fractions of mouse brain.

L B Flexner, P Gambetti, J B Flexner, R B Roberts.

Abstract

Previous experience has led us to suggest that sustained blockage of memory in mice upon administration of puromycin is caused by the persistence of peptidyl-puromycin at synapses. The block can be removed and memory restored by intracerebral injections of water and by subcutaneous or intraperitoneal injections of several psychotropic drugs. The present experiments provide evidence that peptidyl-puromycin persists for long periods in subcellular fractions of synaptosomes (nerve endings), and that the peptide is lost from synaptosomal, but not from mitochondrial, fractions when memory is restored. These findings strengthen our interpretation of the mode of action of puromycin on memory.

Entities: Chemical Species

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Year: 1971 PMID： 5276297 PMCID： PMC391094 DOI： 10.1073/pnas.68.1.26

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

12 in total

1. Memory in mice as affected by intracerebral puromycin.

Authors: J B FLEXNER; L B FLEXNER; E STELLAR
Journal: Science Date: 1963-07-05 Impact factor: 47.728

2. A new and rapid colorimetric determination of acetylcholinesterase activity.

Authors: G L ELLMAN; K D COURTNEY; V ANDRES; R M FEATHER-STONE
Journal: Biochem Pharmacol Date: 1961-07 Impact factor: 5.858

3. Protein measurement with the Folin phenol reagent.

Authors: O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal: J Biol Chem Date: 1951-11 Impact factor: 5.157

4. Biochemical studies of synapses in vitro. I. Protein synthesis.

Authors: L A Autilio; S H Appel; P Pettis; P L Gambetti
Journal: Biochemistry Date: 1968-07 Impact factor: 3.162

5. Studies on memory: the long survival of peptidyl-puromycin in mouse brain.

Authors: L B Flexner; J B Flexner
Journal: Proc Natl Acad Sci U S A Date: 1968-07 Impact factor: 11.205

6. Effect of acetoxycycloheximide and of an acetoxycycloheximide-puromycin mixture on cerebral protein synthesis and memory in mice.

Authors: L B Flexner; J B Flexner
Journal: Proc Natl Acad Sci U S A Date: 1966-02 Impact factor: 11.205

7. Memory in mice analyzed with antibiotics. Antibiotics are useful to study stages of memory and to indicate molecular events which sustain memory.

Authors: L B Flexner; J B Flexner; R B Roberts
Journal: Science Date: 1967-03-17 Impact factor: 47.728

3. Blockade of beta 1- but not of beta 2-adrenergic receptors replicates propranolol's suppression of the cerebral spread of an engram in mice.

Authors: J B Flexner; L B Flexner; A C Church; T C Rainbow; D J Brunswick
Journal: Proc Natl Acad Sci U S A Date: 1985-11 Impact factor: 11.205

Review 4. Brain-specific aminopeptidase: from enkephalinase to protector against neurodegeneration.

Authors: Koon-Sea Hui
Journal: Neurochem Res Date: 2007-05-03 Impact factor: 3.996

5. Protein turnover during maturation of mouse brain tissue.

Authors: B E Gilbert; T C Johnson
Journal: J Cell Biol Date: 1972-04 Impact factor: 10.539

5 in total

Studies on memory: distribution of peptidyl-puromycin in subcellular fractions of mouse brain.

1. Memory in mice as affected by intracerebral puromycin.

2. A new and rapid colorimetric determination of acetylcholinesterase activity.

3. Protein measurement with the Folin phenol reagent.

4. Biochemical studies of synapses in vitro. I. Protein synthesis.

5. Studies on memory: the long survival of peptidyl-puromycin in mouse brain.

6. Effect of acetoxycycloheximide and of an acetoxycycloheximide-puromycin mixture on cerebral protein synthesis and memory in mice.

7. Memory in mice analyzed with antibiotics. Antibiotics are useful to study stages of memory and to indicate molecular events which sustain memory.

8. Puromycin: action on neuronal mitochondria.

9. Some evidence for the involvement of adrenergic sites in the memory trace.

10. Further observations on restoration of memory lost after treatment with puromycin.

1. The effects of emetine hydrochloride on brain protein synthesis and on dark avoidance response in the goldfish.

Review 2. Role of RNA and protein in memory storage: a review.

3. Blockade of beta 1- but not of beta 2-adrenergic receptors replicates propranolol's suppression of the cerebral spread of an engram in mice.

Review 4. Brain-specific aminopeptidase: from enkephalinase to protector against neurodegeneration.

5. Protein turnover during maturation of mouse brain tissue.