Literature DB >> 5276281

Mitotic separation of two human X-linked genes in man--mouse somatic cell hybrids.

O J Miller, P R Cook, P Meera Khan, S Shin, M Siniscalco.   

Abstract

SIX INTERSPECIFIC SOMATIC HYBRID CELL LINES WERE DERIVED FROM A MOUSE LINE DEFICIENT IN HYPOXANTHINE: guanine phosphoribosyltransferase (HGPRT) and human diploid cells with normal enzyme activity. Human HGPRT was present in all six hybrids and the clones derived from them. However, in two of the six, and in some clones from another two, human glucose-6-phosphate dehydrogenase (G6PD) was absent. Since the structural loci for both these enzymes are X-linked in man, these findings suggest that these two loci have separated quite frequently through chromosome breakage and that they must be rather far apart on the X chromosome.

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Year:  1971        PMID： 5276281      PMCID： PMC391174          DOI： 10.1073/pnas.68.1.116

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  18 in total

1.  THREE DEGREES OF GUANYLIC ACID--INOSINIC ACID PYROPHOSPHORYLASE DEFICIENCY IN MOUSE FIBROBLASTS.

Authors:  J W LITTLEFIELD
Journal:  Nature       Date:  1964-09-12       Impact factor: 49.962

2.  DEMONSTRATION OF TWO POPULATIONS OF CELLS IN THE HUMAN FEMALE HETEROZYGOUS FOR GLUCOSE-6-PHOSPHATE DEHYDROGENASE VARIANTS.

Authors:  R G DAVIDSON; H M NITOWSKY; B CHILDS
Journal:  Proc Natl Acad Sci U S A       Date:  1963-09       Impact factor: 11.205

3.  Erythrocyte glucose-6-phosphate dehydrogenase deficiency: evidence of differences between Negroes and Caucasians with respect to this genetically determined trait.

Authors:  P A MARKS; R T GROSS
Journal:  J Clin Invest       Date:  1959-12       Impact factor: 14.808

4.  Chromosomal damage of human cells induced by Sendai virus.

Authors:  E Saksela; P Aula; K Cantell
Journal:  Ann Med Exp Biol Fenn       Date:  1965

5.  Population genetic studies in the Congo. I. Glucose-6-phosphate dehydrogenase deficiency, hemoglobin S, and malaria.

Authors:  A G Motulsky; J Vandepitte; G R Fraser
Journal:  Am J Hum Genet       Date:  1966-11       Impact factor: 11.025

6.  Isolation and properties of hybrids between somatic mouse and Chinese hamster cells.

Authors:  L J Scaletta; N B Rushforth; B Ephrussi
Journal:  Genetics       Date:  1967-09       Impact factor: 4.562

7.  X-linked hypoxanthine-guanine phosphoribosyl transferase deficiency: heterozygote has two clonal populations.

Authors:  B R Migeon; V M Der Kaloustian; W L Nyhan; W J Yough; B Childs
Journal:  Science       Date:  1968-04-26       Impact factor: 47.728

8.  Enzyme defect associated with a sex-linked human neurological disorder and excessive purine synthesis.

Authors:  J E Seegmiller; F M Rosenbloom; W N Kelley
Journal:  Science       Date:  1967-03-31       Impact factor: 47.728

9.  Human-mouse hybrid cell lines containing partial complements of human chromosomes and functioning human genes.

Authors:  M C Weiss; H Green
Journal:  Proc Natl Acad Sci U S A       Date:  1967-09       Impact factor: 11.205

10.  HYBRID CELLS DERIVED FROM MOUSE AND MAN: ARTIFICIAL HETEROKARYONS OF MAMMALIAN CELLS FROM DIFFERENT SPECIES.

Authors:  H HARRIS; J F WATKINS
Journal:  Nature       Date:  1965-02-13       Impact factor: 49.962
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  24 in total

1.  Results and prospects of chromosomal gene transfer between cultured mammalian cells.

Authors:  K Willecke
Journal:  Theor Appl Genet       Date:  1978-05       Impact factor: 5.699

2.  Rapid prenatal diagnosis of HG-PRT deficiency using ultra-microchemical methods.

Authors:  P Hösli; C H de Bruyn; F J Oerlemans; M Verjaal; R E Nobrega
Journal:  Hum Genet       Date:  1977-06-30       Impact factor: 4.132

3.  Isolation and subregional mapping of an arbitrary cloned probe detecting a common RFLP on human chromosome 2.

Authors:  G N Davatelis
Journal:  Am J Hum Genet       Date:  1985-09       Impact factor: 11.025

4.  Chromosomes of older humans are more prone to aminopterine-induced breakage.

Authors:  D Esposito; G Fassina; P Szabo; P De Angelis; L Rodgers; M Weksler; M Siniscalco
Journal:  Proc Natl Acad Sci U S A       Date:  1989-02       Impact factor: 11.205

Review 5.  Utilization of somatic cell hybrids for genetic studies in man.

Authors:  K H Grzeschik
Journal:  Humangenetik       Date:  1973

6.  Cytological mapping of human X-linked genes by use of somatic cell hybrids involving an X-autosome translocation (mouse-hamster-human X-linked markers).

Authors:  K H Grzeschik; P W Allderdice; A Grzeschik; J M Opitz; O J Miller; M Siniscalco
Journal:  Proc Natl Acad Sci U S A       Date:  1972-01       Impact factor: 11.205

7.  Genetics of human-mouse somatic cell hybrids: linkage of human genes for lactate dehydrogenase-A and esterase-A 4 .

Authors:  T B Shows
Journal:  Proc Natl Acad Sci U S A       Date:  1972-02       Impact factor: 11.205

8.  X-linkage of human phosphoglycerate kinase confirmed in man-mouse and man-Chinese hamster somatic cell hybrids.

Authors:  P Meera Khan; A Westerveld; K H Grzeschik; B F Deys; O M Garson; M Siniscalco
Journal:  Am J Hum Genet       Date:  1971-11       Impact factor: 11.025

9.  Entrapment of metaphase chromosomes into phospholipid vesicles (lipochromosomes): carrier potential in gene transfer.

Authors:  A B Mukherjee; S Orloff; J D Butler; T Triche; P Lalley; J D Schulman
Journal:  Proc Natl Acad Sci U S A       Date:  1978-03       Impact factor: 11.205

Review 10.  Hypoxanthine-guanine phosphoribosyl transferase deficiency.

Authors:  C H de Bruyn
Journal:  Hum Genet       Date:  1976-02-29       Impact factor: 4.132
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