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Literature DB >> 527601

Localization of S-[methyl-14 C]adenosyl-L-methionine in pregnant mice and fetuses as determined by autoradiography.

G F Placidi, P Fornaro, M Guarneri, G Stramentinoli.

Abstract

The distribution of S-[methyl-14C]Adenosyl-L-methionine has been examined in pregnant mice using an autoradiographic technique. The results indicate that the compound crosses the placental barrier quite slowly and accumulates in some fetal tissues such as intestine, liver, kidney, eye and lung. The highest concentration is reached 12 hours after i.v. administration of the compound. In the placenta the labelling can be detected for a long time after administering the radioactive compound.

Entities: Chemical Species

Mesh：

Substances：
S-Adenosylmethionine

Year: 1979 PMID： 527601 DOI： 10.1007/BF03189419

Source DB: PubMed Journal: Eur J Drug Metab Pharmacokinet ISSN： 0378-7966 Impact factor: 2.441

19 in total

1. [Pharmacological aspects of S-adenosyl-L-methionone in hepatology. (A) Biochemical signs. (B) Acute, chronic and fetal toxicity. (C) Biochemical and morphohistochemical changes in control rats and rats treated with S-adenosyl-L-methionine after experimental poisoning with various agents].

Authors: G Stramentinoli; C Pezzoli; E Catto
Journal: Minerva Med Date: 1975-05-02 Impact factor: 4.806

Review 3. S-adenosyl-L-methionine. A review of its pharmacological properties and therapeutic potential in liver dysfunction and affective disorders in relation to its physiological role in cell metabolism.

Authors: H A Friedel; K L Goa; P Benfield
Journal: Drugs Date: 1989-09 Impact factor: 9.546

3 in total

Localization of S-[methyl-14 C]adenosyl-L-methionine in pregnant mice and fetuses as determined by autoradiography.

1. [Pharmacological aspects of S-adenosyl-L-methionone in hepatology. (A) Biochemical signs. (B) Acute, chronic and fetal toxicity. (C) Biochemical and morphohistochemical changes in control rats and rats treated with S-adenosyl-L-methionine after experimental poisoning with various agents].

2. Studies on the distribution and fate of S35-labelled benzylpenicillin in the body.

3. Biosynthesis of phosphatidyl choline during prenatal development of the rat lung.

4. Uptake of S-adenosyl-L-methionine by rabbit erythrocytes.

5. Protective role of S-adenosyl-L-methionine on liver injury induced by D-galactosamine in rats.

6. Uptake of adenosylmethionine and related sulfur compounds by isolated rat liver.

7. Metabolism and cerebral energy state: effect of acute hyperammonemia in beagle dog.

8. Comparison of the composition and surface activity of "alveolar" and whole lung lipids in the dog.

9. In vivo studies on pathways for the biosynthesis of lecithin in the rat.

10. [S-adenosylmethionine as a regulator of protein synthesis. Influence on plasmatic fibrinogen].

1. Simplified enzymatic synthesis and biodistribution of 11C-S-adenosyl-L-methionine.

2. The kinetics and dynamics of three kinds of radioactive methionine after i.v. administration in mice.

Review 3. S-adenosyl-L-methionine. A review of its pharmacological properties and therapeutic potential in liver dysfunction and affective disorders in relation to its physiological role in cell metabolism.