Literature DB >> 5275380

Reversal of malignant transformation by tumor DNA.

B C Halpern, R M Halpern, S Q Chaney, R A Smith.   

Abstract

Walker-256 carcinosarcoma cells grown in tissue culture medium containing inhibitory DNA prepared from the tumor are shown to have an unaltered growth in vitro, but a diminished capacity to produce malignant tumors on injection into the rat. Coincident with this change in virulence is the induction of tRNA methylase inhibitors in these malignant cells. Within days after the DNA is removed from the growth medium, the tRNA methylase inhibitors disappear and the oncogenicity reappears.

Entities:  

Mesh：

Substances：

Year:  1970        PMID： 5275380      PMCID： PMC283435          DOI： 10.1073/pnas.67.4.1827

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  14 in total

1.  Partition of double-stranded and single-stranded deoxyribonucleic acid.

Authors:  P A ALBERTSSON
Journal:  Arch Biochem Biophys       Date:  1962-09       Impact factor: 4.013

2.  Growth-promoting properties of pyruvate oxal-acetate, and alpha-ketoglutarate for isolated Walker carcinosarcoma 256 cells.

Authors:  R E NEUMAN; T A McCOY
Journal:  Proc Soc Exp Biol Med       Date:  1958-06

3.  Nutrition needs of mammalian cells in tissue culture.

Authors:  H EAGLE
Journal:  Science       Date:  1955-09-16       Impact factor: 47.728

4.  Measurement of cell growth in tissue culture with a phenol reagent (folin-ciocalteau).

Authors:  V I OYAMA; H EAGLE
Journal:  Proc Soc Exp Biol Med       Date:  1956-02

5.  Methylation of transfer RNA and of ribosomal RNA in rat liver in the intact animal and the effect of carcinogens.

Authors:  V M Craddock
Journal:  Biochim Biophys Acta       Date:  1969-12-16

6.  Altered transfer RNA methylase patterns induced by an avian oncogenic virus.

Authors:  B Hacker; L R Mandel
Journal:  Biochim Biophys Acta       Date:  1969-09-17

7.  TRNA methylases in tumors of animal and human origin.

Authors:  E Tsutsui; P R Srinivasan; E Borek
Journal:  Proc Natl Acad Sci U S A       Date:  1966-09       Impact factor: 11.205

8.  Transfer RNA methylase inhibitors in neoplastic and normal rat tissue.

Authors:  S Q Chaney; B C Halpern; R M Halpern; R A Smith
Journal:  Biochem Biophys Res Commun       Date:  1970-09-10       Impact factor: 3.575

9.  Inhibition of neoplastic cell growth by autogenous DNA.

Authors:  R M Halpern; B C Halpern; K A Conklin; R A Smith
Journal:  Proc Natl Acad Sci U S A       Date:  1968-09       Impact factor: 11.205

10.  Clonal growth in vitro of epithelial cells from normal human tissues.

Authors:  S J CIECIURA; P I MARCUS; T T PUCK
Journal:  J Exp Med       Date:  1956-10-01       Impact factor: 14.307
View more
  2 in total

1.  Casticin inhibits the activity of transcription factor Sp1 and the methylation of RECK in MGC803 gastric cancer cells.

Authors:  Fan Yang; Kefei He; Li Huang; Lingyan Zhang; Aixue Liu; Jiren Zhang
Journal:  Exp Ther Med       Date:  2016-12-27       Impact factor: 2.447

2.  Effect of methionine replacement by homocystine in cultures containing both malignant rat breast carcinosarcoma (Walker-256) cells and normal adult rat liver fibroblasts.

Authors:  B C Halpern; R Ezzell; D N Hardy; B R Clark; H Ashe; R M Halpern; R A Smith
Journal:  In Vitro       Date:  1975 Jan-Feb
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.