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Literature DB >> 5274459

Altered nucleic acids of antibody-forming tissues.

Abstract

RNA.DNA hybridization experiments suggest differences between the DNA from the liver and spleen of the same animal (rabbit) and between the RNAs from lymph nodes stimulated by different antigens. A larger proportion of spleen DNA than of liver DNA was complementary to the RNA isolated from antigen-stimulated lymph nodes. No difference between liver and spleen DNA was observed in hybrids formed with RNA from lymph nodes of nonimmune animals. This suggests the presence of unique or redundant genes coding for immunoglobulin polypeptide chains in antibody-forming cells.

Entities: Species

Mesh：

Substances：
Tritium
RNA
DNA

Year: 1970 PMID： 5274459 PMCID： PMC283352 DOI： 10.1073/pnas.67.3.1299

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

29 in total

1. CONTROL OF VIRAL MESSENGER RNA AFTER LAMBDA PHAGE INFECTION AND INDUCTION.

Authors: W S SLY; H ECHOLS; J ADLER
Journal: Proc Natl Acad Sci U S A Date: 1965-02 Impact factor: 11.205

2. LOCALIZATION OF DNA COMPLEMENTARY TO RIBOSOMAL RNA IN THE NUCLEOLUS ORGANIZER REGION OF DROSOPHILA MELANOGASTER.

Authors: F M RITOSSA; S SPIEGELMAN
Journal: Proc Natl Acad Sci U S A Date: 1965-04 Impact factor: 11.205

3. The appearance of new species of RNA in the mouse spleen after immunization as detected by molecular hybridization.

Authors: E P Cohen
Journal: Proc Natl Acad Sci U S A Date: 1967-03 Impact factor: 11.205

4. DNA-RNA hybridization studies of myeloma tumors in mice.

Authors: L J Greenberg; J W Uhr
Journal: Proc Natl Acad Sci U S A Date: 1967-11 Impact factor: 11.205

5. Titration of the gene sites on DNA by DNA-RNA hybridization. I. Problem of measurement.

Authors: D Kennell; A Kotoulas
Journal: J Mol Biol Date: 1968-05-28 Impact factor: 5.469

6. Related base sequences in the DNA of simple and complex organisms. 3. Variability in the base sequence of the reduplicated genes for ribosomal RNA in the rabbit.

Authors: R L Moore; B J McCarthy
Journal: Biochem Genet Date: 1968-06 Impact factor: 1.890

Altered nucleic acids of antibody-forming tissues.

1. CONTROL OF VIRAL MESSENGER RNA AFTER LAMBDA PHAGE INFECTION AND INDUCTION.

2. LOCALIZATION OF DNA COMPLEMENTARY TO RIBOSOMAL RNA IN THE NUCLEOLUS ORGANIZER REGION OF DROSOPHILA MELANOGASTER.

3. The appearance of new species of RNA in the mouse spleen after immunization as detected by molecular hybridization.

4. DNA-RNA hybridization studies of myeloma tumors in mice.

5. Titration of the gene sites on DNA by DNA-RNA hybridization. I. Problem of measurement.

6. Related base sequences in the DNA of simple and complex organisms. 3. Variability in the base sequence of the reduplicated genes for ribosomal RNA in the rabbit.

7. Two rapidly labeled RNA species in the polysomes of antibody-producing lymphoid tissue.

8. Gene regulation for higher cells: a theory.

9. Recognition of ribosomal RNA sites in DNA. II. The HeLa cell system.

10. Biosynthesis of RNA in antibody-producing tissues.

1. Excretion of deoxyribonucleic acid by lymphocytes stimulated with phytohemagglutinin or antigen.