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Literature DB >> 5273448

Immunoglobulin synthesis and secretion. V. Incorporation of leucine and glucosamine into immunoglobulin on free and bound polyribosomes.

Abstract

Mouse myeloma cells pulse-labeled in vitro with (3)H-leucine or (3)H-glucosamine were fractionated on sucrose gradients, and membrane-bound and free polyribosomes were separated. Nascent polypeptides released from polyribosomes were precipitated with antiserum specific for mouse immunoglobulin. The results indicate that immunoglobulin is synthesized preferentially by bound polyribosomes.

Entities: Chemical Disease Species

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Year: 1970 PMID： 5273448 PMCID： PMC335804 DOI： 10.1073/pnas.66.4.1183

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

28 in total

1. Polyribosomal synthesis and assembly of the H and L chains of gamma globulin.

Authors: A L Shapiro; M D Scharff; J V Maizel; J W Uhr
Journal: Proc Natl Acad Sci U S A Date: 1966-07 Impact factor: 11.205

Review 2. On the biological role of glycoproteins.

Authors: E H Eylar
Journal: J Theor Biol Date: 1966-01 Impact factor: 2.691

3. Biosynthesis of glycoprotein by liver. The incorporation in vivo of 14C-glucosamine into protein-bound hexosamine and sialic acid of rat liver subcellular fractions.

Authors: G R Lawford; H Schachter
Journal: J Biol Chem Date: 1966-11-25 Impact factor: 5.157

4. The synthesis and storage of protein by isolated lymphoid cells, examined by autoradiography with the electron microscope.

Authors: S L Clark
Journal: Am J Anat Date: 1966-11

5. Synthesis and transfer of amylase in pigeon pancreatic micromosomes.

Authors: C M Redman; P Siekevitz; G E Palade
Journal: J Biol Chem Date: 1966-03-10 Impact factor: 5.157

6. Biosynthesis of immunoglobulins: the separate classes of polyribosomes synthesizing heavy and light chains.

Authors: A R Williamson; B A Askonas
Journal: J Mol Biol Date: 1967-01-28 Impact factor: 5.469

7. Studies on free and membrane-bound ribosomes in rat liver. II. Interaction of ribosomes and membranes.

Authors: G Blobel; V R Potter
Journal: J Mol Biol Date: 1967-06-14 Impact factor: 5.469

8. Ribosomes in rat liver: an estimate of the percentage of free and membrane-bound ribosomes interacting with messenger RNA in vivo.

Authors: G Blobel; V R Potter
Journal: J Mol Biol Date: 1967-09-28 Impact factor: 5.469

9. Studies on the protein-synthesizing activity of the ribosomes of rat liver. The activity of free polysomes.

Authors: P N Campbell; G Serck-Hanssen; E Lowe
Journal: Biochem J Date: 1965-11 Impact factor: 3.857

10. Ultrastructural localization of antibody in differentiating plasma cells.

Authors: E H Leduc; S Avrameas; M Bouteille
Journal: J Exp Med Date: 1968-01-01 Impact factor: 14.307

15 in total

1. Localization of polyribosomes containing alkaline phosphatase nascent polypeptides on membranes of Escherichia coli.

Authors: R Cancedda; M J Schlesinger
Journal: J Bacteriol Date: 1974-01 Impact factor: 3.490

2. Differences in the incorporation of [3H]-glucosamine into nascent polypeptide chains on free polysomes and two fractions of membrane-bound polysomes in mouse myeloma cells.

Authors: I F Pryme; A M Svardal
Journal: Mol Biol Rep Date: 1979-02-15 Impact factor: 2.316

Review 3. Immunoglobulins.

Authors: J Bradley
Journal: J Med Genet Date: 1974-03 Impact factor: 6.318

4. The vectorial release of nascent immunoglobulin peptides.

Authors: M J Bevan
Journal: Biochem J Date: 1971-03 Impact factor: 3.857

5. Variation in microsomal subfractions obtained from normal animal tissues and transformed cells following cell disruption by nitrogen cavitation.

Authors: I F Pryme; A M Svardal; J Skorve
Journal: Mol Cell Biochem Date: 1981-02-11 Impact factor: 3.396

6. Studies on the glycosylation of hydroxylysine residues during collagen biosynthesis and the subcellular localization of collagen galactosyltransferase and collagen glucosyltransferase in tendon and cartilage cells.

Authors: R Harwood; M E Grant; D S Jackson
Journal: Biochem J Date: 1975-11 Impact factor: 3.857

10. Biosynthesis of the carbohydrate portion of immunoglobulins. Incorporation of radioactive fucose into immunoglobulin G1 synthesized and secreted by mouse plasma-cell tumour MOPC 21.

Authors: F Melchers
Journal: Biochem J Date: 1971-11 Impact factor: 3.857