Literature DB >> 5272311

Role of adrenal cortical function in toxicity of polyriboinosinic-polyribocytidylic acid and its component homopolymers.

M S Zedeck, H Marquardt, S S Sternberg, M Fleisher, L D Hamilton.   

Abstract

Adrenalectomized rats are 1000 times more sensitive to lethal effects of the double-stranded complex polyriboinosinic.polyribocytidylic acid than intact rats. They are protected from such lethal effects by corticosterone. The complex can rapidly induce diffuse, severe necrosis of villous epithelium in small intestine without damage in crypts. Injection of the individual homopolymers, polyriboinosinic acid and polyribocytidylic acid, separately but in rapid succession is at least as lethal as injection of the complex.

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Year:  1970        PMID： 5272311      PMCID： PMC283185          DOI： 10.1073/pnas.67.1.180

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  7 in total

1.  Screening steroids against a spectrum of tumors.

Authors:  C C STOCK; K SUGIURA
Journal:  Ann N Y Acad Sci       Date:  1958-12-05       Impact factor: 5.691

2.  Fasting ketosis in the adrenalectomized and cortisone-treated rat.

Authors:  M G ENGEL; F L ENGEL
Journal:  Endocrinology       Date:  1954-11       Impact factor: 4.736

3.  Uptake of polynucleotides by intact mammalian cells (IV): synthetic homoribopolynucleotides.

Authors:  P L Schell
Journal:  Z Naturforsch B       Date:  1968-08       Impact factor: 1.047

4.  Biochemical and pathological effects of methylazoxymethanol acetate, a potent carcinogen.

Authors:  M S Zedeck; S S Sternberg; R W Poynter; J McGowan
Journal:  Cancer Res       Date:  1970-03       Impact factor: 12.701

5.  Inducers of interferon and host resistance. II. Multistranded synthetic polynucleotide complexes.

Authors:  A K Field; A A Tytell; G P Lampson; M R Hilleman
Journal:  Proc Natl Acad Sci U S A       Date:  1967-09       Impact factor: 11.205

6.  Inhibition of tumor growth by polyinosinic-polycytidylic acid.

Authors:  H B Levy; L W Law; A S Rabson
Journal:  Proc Natl Acad Sci U S A       Date:  1969-02       Impact factor: 11.205

7.  Inhibition of herpes simplex virus by synthetic double-stranded RNA (polyriboadenylic and polyribouridylic acids and polyriboinosinic and polyribocytidylic acids).

Authors:  L D Hamilton; V I Babcock; C M Southam
Journal:  Proc Natl Acad Sci U S A       Date:  1969-11       Impact factor: 11.205
  7 in total
  2 in total

1.  The protective effect of the interferon inducers tilorone hydrochloride and Poly I:C on experimental tick-borne encephalitis in mice.

Authors:  H Hofmann; C Kunz
Journal:  Arch Gesamte Virusforsch       Date:  1972

2.  Interferon production linked to toxicity of polyriboinosinic acid-polyribocytidylic acid.

Authors:  E De Clercq; W E Stewart; P De Somer
Journal:  Infect Immun       Date:  1972-09       Impact factor: 3.441
  2 in total

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