Literature DB >> 5271271

Radiation-induced osteosarcoma in the rat as a model for osteosarcoma in man.

L M Cobb.   

Abstract

A technique is described for the local induction of osteosarcoma in the rat by implanting (32)P-impregnated polyvinyl chloride discs into the distal femoral metaphysis. The incidence of osteosarcomata after 18 months was 28%. A comparison is made of the pathology of the radiation-induced osteosarcoma in the rat and the "spontaneous" osteosarcoma in man. The possible value of the rat osteosarcoma model is discussed.

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Year:  1970        PMID： 5271271      PMCID： PMC2008590          DOI： 10.1038/bjc.1970.34

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  2 in total

1.  Production of malignant tumors in rats with radioactive phosphorus.

Authors:  S KOLETSKY; F J BONTE; H L FRIEDELL
Journal:  Cancer Res       Date:  1950-03       Impact factor: 12.701

2.  Beryllium induced sarcomas of the rabbit tibia.

Authors:  E Tapp
Journal:  Br J Cancer       Date:  1966-12       Impact factor: 7.640
  2 in total
  3 in total

1.  A nude mouse model of human osteosarcoma lung metastases for evaluating new therapeutic strategies.

Authors:  S F Jia; L L Worth; E S Kleinerman
Journal:  Clin Exp Metastasis       Date:  1999       Impact factor: 5.150

2.  Gamma-ray induction of malignant tumors in rats.

Authors:  C G Hori; S Warren; W B Patterson; R N Chute
Journal:  Am J Pathol       Date:  1971-11       Impact factor: 4.307

3.  Bone tumours induced in rats with radioactive cerium.

Authors:  H G Delbrück; M Allouche; C Jasmin; M Morin; F Deml; L Anghileri; R Masse; J Lafuma
Journal:  Br J Cancer       Date:  1980-05       Impact factor: 7.640
  3 in total

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