| Literature DB >> 5271169 |
Abstract
Cytochalasin B causes cultured mouse salivary gland epithelium to lose its characteristic shape and to cease undergoing morphogenesis. The drug causes disorganization of the 50 A microfilaments in epithelial cells that are thought to control cell shape because of contractile properties. Upon removal of cytochalasin, epithelia regain normal shape and resume morphogenesis. Exceptionally large bundles of microfilaments appear in such recovered epithelial cells at points where their contractile activity could account for the changes in cell and tissue shape.Entities:
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Year: 1970 PMID: 5271169 PMCID: PMC283052 DOI: 10.1073/pnas.66.2.360
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN: 0027-8424 Impact factor: 11.205