| Literature DB >> 52707 |
I B Chatterjee, S D Gupta, A K Majumder, B K Nandi, N Subramanian.
Abstract
1. In guinea-pigs fed an ascorbic-acid-free diet, as the ascorbic acid levels decreased the histamine levels in blood and urine rose steadily to maxima in about 10-12 days. The elevated histamine levels persisted in the blood and urine of scorbutic guinea-pigs and the histamine levels in lung, gastric mucosa and spleen also increased. The increased histamine content of the urine, blood and other tissues in the ascorbic-acid-depleted condition could be brought back to normal levels by administration of a single dose of ascorbic acid 5 mg/100 g body wt. guinea-pig. 3. The drop in the elevated histamine level was not due to an indirect effect of ascorbic acid on histamine forming capacity, histaminase activity or histamine release.Entities:
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Year: 1975 PMID： 52707 PMCID： PMC1348426 DOI： 10.1113/jphysiol.1975.sp011091
Source DB: PubMed Journal: J Physiol ISSN： 0022-3751 Impact factor: 5.182