Literature DB >> 52680

Peritoneal macrophages as target cells for measuring virus-specific T cell mediated cytotoxicity in vitro.

R M Zinkernagel, P C Doherty.   

Abstract

In inbred or outbred mice lysis of virally modified cells by thymus-derived lymphocytes occurs only within a H-2 compatible system. Peritoneal macrophages provide a convenient source of syngeneic target cells. They are readily infected in vitro with LCM virus, and show high levels of specific 51Cr release when exposed to T cells from LCM immune mice.

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Year:  1975        PMID： 52680     DOI： 10.1016/0022-1759(75)90120-9

Source DB:  PubMed          Journal:  J Immunol Methods        ISSN： 0022-1759            Impact factor:   2.303


  8 in total

1.  Protective activity of secondary effector T cells generated in vitro against ectromelia virus infection in vivo.

Authors:  U Kees; R V Blanden
Journal:  Clin Exp Immunol       Date:  1977-12       Impact factor: 4.330

2.  Dendritic cells stimulate primary human cytolytic lymphocyte responses in the absence of CD4+ helper T cells.

Authors:  J W Young; R M Steinman
Journal:  J Exp Med       Date:  1990-04-01       Impact factor: 14.307

3.  In vitro evidence of cell-mediated immunity after exposure of mice to both live and inactivated rabies virus.

Authors:  T J Wiktor; P C Doherty; H Koprowski
Journal:  Proc Natl Acad Sci U S A       Date:  1977-01       Impact factor: 11.205

4.  Cytotoxic cells induced after Chlamydia psittaci infection in mice.

Authors:  J K Lammert
Journal:  Infect Immun       Date:  1982-03       Impact factor: 3.441

5.  Consequences of a single Ir-gene defect for the pathogenesis of lymphocytic choriomeningitis.

Authors:  J E Allan; P C Doherty
Journal:  Immunogenetics       Date:  1985       Impact factor: 2.846

6.  Nef Is Dispensable for Resistance of Simian Immunodeficiency Virus-Infected Macrophages to CD8+ T Cell Killing.

Authors:  Jennifer N Rainho; Mauricio A Martins; Francesc Cunyat; Ian T Watkins; David I Watkins; Mario Stevenson
Journal:  J Virol       Date:  2015-08-12       Impact factor: 5.103

7.  HLA-D region-associated determinants serve as targets for human cell-mediated lysis.

Authors:  C Feighery; P Stastny
Journal:  J Exp Med       Date:  1979-02-01       Impact factor: 14.307

8.  H-2 compatibility requirement for virus-specific T-cell-mediated cytolysis. The H-2K structure involved is coded by a single cistron defined by H-2Kb mutant mice.

Authors:  R M Zinkernagel
Journal:  J Exp Med       Date:  1976-02-01       Impact factor: 14.307
  8 in total

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