Literature DB >> 5267133

The conformation of cholinergic molecules at nicotinic nerve receptors.

C Chothia, P Pauling.   

Abstract

A correlation of the crystal structure analyses of the potent nicotinic agonists acetylcholine, acetyl-alpha-methylcholine, lactoylcholine, 1,1-dimethyl-4-phenylpiperazine, and nicotine allows one to determine the conformation of cholinergic agonists relevant to nicotinic nerve receptors.

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Year:  1970        PMID： 5267133      PMCID： PMC282930          DOI： 10.1073/pnas.65.3.477

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  6 in total

1.  Stimulant activities of quaternary ammonium compounds on mammalian skeletal muscle.

Authors:  G L WILLEY
Journal:  Br J Pharmacol Chemother       Date:  1955-12

2.  Conformations of acetylcholine.

Authors:  C Chothia; P Pauling
Journal:  Nature       Date:  1968-09-14       Impact factor: 49.962

3.  Calculated minimum energy conformations of acetylcholine.

Authors:  A M Liquori; A Damiani; J L De Coen
Journal:  J Mol Biol       Date:  1968-04-28       Impact factor: 5.469

4.  The cholinergic effects and rates of hydrolysis of conformationally rigid analogs of acetylcholine.

Authors:  C Y Chiou; J P Long; J G Cannon; P D Armstrong
Journal:  J Pharmacol Exp Ther       Date:  1969-04       Impact factor: 4.030

5.  Conformation of cholinergic molecules relevant to acetylcholinesterase.

Authors:  C Chothia; P Pauling
Journal:  Nature       Date:  1969-08-30       Impact factor: 49.962

6.  Structure of acetylcholine and other substrates of cholinergic systems.

Authors:  F G Canepa; P Pauling; H Sörum
Journal:  Nature       Date:  1966-05-28       Impact factor: 49.962
  6 in total
  1 in total

1.  Conformational properties of the acetylcholine receptor as revealed by studies with constrained depolarizing ligands.

Authors:  N H Wassermann; E Bartels; B F Erlanger
Journal:  Proc Natl Acad Sci U S A       Date:  1979-01       Impact factor: 11.205
  1 in total

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