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Literature DB >> 5264150

Effect of the lambda repressor on the binding of RNA polymerase to DNA.

Abstract

Experiments were designed with the aim of understanding the mechanism whereby the lambda repressor inhibits messenger RNA synthesis. Complexes containing lambda DNA and RNA polymerase were isolated from repressed and derepressed lysogens and analyzed for the relative amounts of RNA polymerase per phage genome. The data indicate that the repressor inhibits the binding of RNA polymerase to promoter sites known to be under direct control of the repressor.

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Year: 1969 PMID： 5264150 PMCID： PMC223329 DOI： 10.1073/pnas.64.3.962

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

26 in total

1. Genetic regulatory mechanisms in the synthesis of proteins.

Authors: F JACOB; J MONOD
Journal: J Mol Biol Date: 1961-06 Impact factor: 5.469

2. The production of phage chromosome fragments and their capacity for genetic transfer.

Authors: A D KAISER
Journal: J Mol Biol Date: 1962-04 Impact factor: 5.469

3. Early-late transcription switch: isolation of a lambda DNA-RNA polymerase complex active in the synthesis of late RNA.

Authors: C J Chesterton; M H Green
Journal: Biochem Biophys Res Commun Date: 1968-06-28 Impact factor: 3.575

Review 3. Actions of the rifamycins.

Authors: W Wehrli; M Staehelin
Journal: Bacteriol Rev Date: 1971-09

4. Control of stable ribonucleic acid chain initiation in Escherichia coli during diauxie lag.

Authors: L A Jacobson
Journal: J Bacteriol Date: 1972-02 Impact factor: 3.490

5. State of adenovirus 2 deoxyribonucleic acid in the nucleus and its mode of transcription: studies with isolated viral deoxyribonucleic acid-protein complexes and isolated nuclei.

Authors: R D Wallace; J Kates
Journal: J Virol Date: 1972-04 Impact factor: 5.103

5 in total

Effect of the lambda repressor on the binding of RNA polymerase to DNA.

1. Genetic regulatory mechanisms in the synthesis of proteins.

2. The production of phage chromosome fragments and their capacity for genetic transfer.

3. Early-late transcription switch: isolation of a lambda DNA-RNA polymerase complex active in the synthesis of late RNA.

4. Inhibition of DNA-dependent RNA synthesis by rifamycins.

5. The periodicity of RNA polymerase initiations: a new regulatory feature of transcription.

6. Studies of heat-inducible lambda bacteriophage. I. Order of genetic sites and properties of mutant prophages.

7. Orientation and control of transcription in E. coli phage lambda.

8. Asymmetric distribution of the transcribing regions on the complementary strands of coliphage lambda DNA.

9. Inactivation of the prophage lambda repressor without induction.

10. Specific binding of the lambda phage repressor to lambda DNA.

1. Purification and base composition analysis of phage lambda early promoters.

2. Isolation of a polyoma-nucleoprotein complex from infected mouse-cell cultures.

Review 3. Actions of the rifamycins.

4. Control of stable ribonucleic acid chain initiation in Escherichia coli during diauxie lag.

5. State of adenovirus 2 deoxyribonucleic acid in the nucleus and its mode of transcription: studies with isolated viral deoxyribonucleic acid-protein complexes and isolated nuclei.