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Literature DB >> 5264136

Pre-fork synthesis: a model for DNA replication.

Abstract

A model of DNA replication is presented in which DNA synthesis is continuously initiated from parental strand nicks and occurs, with conservation of helix winding number, ahead of the so-called replicating fork. The fork in this model is the locus of unwinding of already replicated, but presumably unstable, DNA. The model, involving Okazaki's notion of multiple initiation, is based upon the properties of Kornberg's DNA polymerase and accounts for the presence of single-stranded nascent DNA fragments in cell lysates. In addition to acting as sites of initiation, the parental strand nicks are implicated as sites of free rotation allowing unwinding of the replicated DNA.

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Substances：

Year: 1969 PMID： 5264136 PMCID： PMC223344 DOI： 10.1073/pnas.64.3.1065

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

38 in total

1. SEDIMENTATION STUDIES OF THE SIZE AND SHAPE OF DNA.

Authors: F W STUDIER
Journal: J Mol Biol Date: 1965-02 Impact factor: 5.469

2. Enzymatic joining of DNA strands: a novel reaction of diphosphopyridine nucleotide.

Authors: S B Zimmerman; J W Little; C K Oshinsky; M Gellert
Journal: Proc Natl Acad Sci U S A Date: 1967-06 Impact factor: 11.205

3. The enzymatic cleavage of phosphate termini from polynucleotides.

Authors: A Becker; J Hurwitz
Journal: J Biol Chem Date: 1967-03-10 Impact factor: 5.157

4. Deoxyribonucleic acid secondary structure in the region of the replication point.

Authors: C Kidson
Journal: J Mol Biol Date: 1966-05 Impact factor: 5.469

5. Linkage of polynucleotides through phosphodiester bonds by an enzyme from Escherichia coli.

Authors: B M Olivera; I R Lehman
Journal: Proc Natl Acad Sci U S A Date: 1967-05 Impact factor: 11.205

6. Enzymatic breakage and joining of deoxyribonucleic acid, I. Repair of single-strand breaks in DNA by an enzyme system from Escherichia coli infected with T4 bacteriophage.

Authors: B Weiss; C C Richardson
Journal: Proc Natl Acad Sci U S A Date: 1967-04 Impact factor: 11.205

5. Monofunctional alkylating agent-induced inactivation, mutagenesis and DNA degradation in an Escherichia coli mutant deficient in DNA polymerase.

Authors: G B Smirnov; Y N Favorskaya; A G Skavronskaya
Journal: Mol Gen Genet Date: 1971

6. The occurrence of two types of synthesis of deoxyribonucleic acid during normal growth in Bacillus subtilis.

Authors: W J Harris
Journal: Biochem J Date: 1973-10 Impact factor: 3.857

7. Sensitivity of intracellular bacteriophage lambda to colicin CA42-E2.

Authors: R R Hull; P Reeves
Journal: J Virol Date: 1971-10 Impact factor: 5.103

8. Temperature-sensitive mutants for the replication of plasmids in Escherichia coli: requirement for deoxyribonucleic acid polymerase I in the replication of the plasmid ColE 1 .

Authors: D T Kingsbury; D R Helinski
Journal: J Bacteriol Date: 1973-06 Impact factor: 3.490

9. Role of gene 52 in bacteriophage T4 DNA synthesis.

Authors: Y Naot; C Shalitin
Journal: J Virol Date: 1973-06 Impact factor: 5.103

9 in total

Pre-fork synthesis: a model for DNA replication.

1. SEDIMENTATION STUDIES OF THE SIZE AND SHAPE OF DNA.

2. Enzymatic joining of DNA strands: a novel reaction of diphosphopyridine nucleotide.

3. The enzymatic cleavage of phosphate termini from polynucleotides.

4. Deoxyribonucleic acid secondary structure in the region of the replication point.

5. Linkage of polynucleotides through phosphodiester bonds by an enzyme from Escherichia coli.

6. Enzymatic breakage and joining of deoxyribonucleic acid, I. Repair of single-strand breaks in DNA by an enzyme system from Escherichia coli infected with T4 bacteriophage.

7. The enzymatic repair of DNA. I. Formation of circular lambda-DNA.

8. A unique property of the replicating region of chromosomal DNA.

9. Replication of double-strand nucleic acids.

10. Polynucleotide cellulose as a substrate for a polynucleotide ligase induced by phage T4.

1. Filamentous bacterial viruses. V. Asymmetric replication of fd duplex deoxyribonucleic acid.

2. Ribonucleotides covalently linked to deoxyribonucleic acid in T4 bacteriophage.

3. Regions of single-stranded DNA in the growing points of replicating bacteriophage T7 chromosomes.

Review 4. [Virus and DNA replication. Studies in bacteriophage X174].

5. Monofunctional alkylating agent-induced inactivation, mutagenesis and DNA degradation in an Escherichia coli mutant deficient in DNA polymerase.

6. The occurrence of two types of synthesis of deoxyribonucleic acid during normal growth in Bacillus subtilis.

7. Sensitivity of intracellular bacteriophage lambda to colicin CA42-E2.

8. Temperature-sensitive mutants for the replication of plasmids in Escherichia coli: requirement for deoxyribonucleic acid polymerase I in the replication of the plasmid ColE 1 .

9. Role of gene 52 in bacteriophage T4 DNA synthesis.