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Literature DB >> 5264133

Peptide formation mediated by hydrogen cyanide tetramer: a possible prebiotic process.

Abstract

Chemical evolution on the primitive earth must have involved condensation of alpha-amino acids to peptides. Under aqueous conditions consistent with current conceptions of primordial waters, heating glycerine with the hydrogen cyanide tetramer, diaminomaleonitrile, yields dipeptide. If nitrogen was cycled through primordial waters as cyanide, peptide synthesis by stepwise tetramer-mediated condensation of alpha-amino acids would have been a plausible process.

Entities: Chemical

Mesh：

Substances：

Year: 1969 PMID： 5264133 PMCID： PMC223336 DOI： 10.1073/pnas.64.3.1011

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

13 in total

1. CYANAMIDE: A POSSIBLE KEY COMPOUND IN CHEMICAL EVOLUTION.

Authors: G STEINMAN; R M LEMMON; M CALVIN
Journal: Proc Natl Acad Sci U S A Date: 1964-07 Impact factor: 11.205

2. PEPTIDE SYNTHESIS FROM AMINO ACIDS IN AQUEOUS SOLUTION.

Authors: C PONNAMPERUMA; E PETERSON
Journal: Science Date: 1965-03-26 Impact factor: 47.728

3. THE FORMATION OF CONDENSED PHOSPHATE IN AQUEOUS SOLUTION.

Authors: A Beck; L E Orgel
Journal: Proc Natl Acad Sci U S A Date: 1965-09 Impact factor: 11.205

4. Chemical events on the primitive Earth.

Authors: P H Abelson
Journal: Proc Natl Acad Sci U S A Date: 1966-06 Impact factor: 11.205

5. On the Early Chemical History of the Earth and the Origin of Life.

Authors: H C Urey
Journal: Proc Natl Acad Sci U S A Date: 1952-04 Impact factor: 11.205

6. Studies in prebiotic synthesis. II. Synthesis of purine precursors and amino acids from aqueous hydrogen cyanide.

Authors: R A Sanchez; J P Ferris; L E Orgel
Journal: J Mol Biol Date: 1967-12-14 Impact factor: 5.469

7. Prebiotic synthesis: phosphorylation in aqueous solution.

Authors: R Lohrmann; L E Orgel
Journal: Science Date: 1968-07-05 Impact factor: 47.728

8. Ammonium ion concentration in the primitive ocean.

Authors: J L Bada; S L Miller
Journal: Science Date: 1968-01-26 Impact factor: 47.728

9. Studies on prebiotic synthesis. I. Aminomalononitrile and 4-amino-5-cyanoimidazole.

Authors: J P Ferris; L E Orgel
Journal: J Am Chem Soc Date: 1966-08-20 Impact factor: 15.419

10. Cyanamide Formation under Primitive Earth Conditions.

Authors: A Schimpl; R M Lemmon; M Calvin
Journal: Science Date: 1965-01-08 Impact factor: 47.728

10 in total

1. The investigation of the HCN derivative diiminosuccinonitrile as a prebiotic condensing agent. The formation of phosphate esters.

Authors: J P Ferris; H Yanagawa; P A Dudgeon; W J Hagan; T E Mallare
Journal: Orig Life Evol Biosph Date: 1984 Impact factor: 1.950

Peptide formation mediated by hydrogen cyanide tetramer: a possible prebiotic process.

1. CYANAMIDE: A POSSIBLE KEY COMPOUND IN CHEMICAL EVOLUTION.

2. PEPTIDE SYNTHESIS FROM AMINO ACIDS IN AQUEOUS SOLUTION.

3. THE FORMATION OF CONDENSED PHOSPHATE IN AQUEOUS SOLUTION.

4. Chemical events on the primitive Earth.

5. On the Early Chemical History of the Earth and the Origin of Life.

6. Studies in prebiotic synthesis. II. Synthesis of purine precursors and amino acids from aqueous hydrogen cyanide.

7. Prebiotic synthesis: phosphorylation in aqueous solution.

8. Ammonium ion concentration in the primitive ocean.

9. Studies on prebiotic synthesis. I. Aminomalononitrile and 4-amino-5-cyanoimidazole.

10. Cyanamide Formation under Primitive Earth Conditions.

1. The investigation of the HCN derivative diiminosuccinonitrile as a prebiotic condensing agent. The formation of phosphate esters.

2. The effect of clays on the oligomerization of HCN.

3. Quantum chemical study of relative reactivities of a series of amines and nitriles: relevance to prebiotic chemistry.

4. Abiotic origin of biopolymers.

Review 5. Chemical evolution. Recent syntheses of bioorganic molecules.

6. Direct synthesis of polypeptides. Polycondensation of alpha-amino acids by polymetaphosphate esters.

7. Polymerization of amino acids under primitive earth conditions.

8. Prebiotic condensation reactions in an aqueous medium: a review of condensing agents.

9. Potentially prebiotic syntheses of condensed phosphates.

10. Polymerization of beta-amino acids in aqueous solution.