Literature DB >> 526183

Hair cell degeneration in guinea pigs intoxicated with kanamycin during intrauterine life; a structural and ultrastructural study.

A Uziel, J Gabrion, R Romand.   

Abstract

The structural ototoxic effect of kanamycin during intrauterine life has been shown in guinea pigs. The extent of the loss mostly affected the outer hair cells of the basal part of the cochlea. Ultrastructural studies demonstrated a hair cell degeneration pattern similar to that previously described in adult animals following antibiotic intoxication.

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Year:  1979        PMID： 526183     DOI： 10.1007/BF01108777

Source DB:  PubMed          Journal:  Arch Otorhinolaryngol        ISSN： 0302-9530


  5 in total

1.  EFFECT OF KANAMYCIN ON COCHLEAR CYTOARCHITECTURE.

Authors:  J E HAWKINS; H ENGSTROEM
Journal:  Acta Otolaryngol Suppl       Date:  1964

2.  The ototoxicity of kanamycin in guinea pigs.

Authors:  P H WARD; C FERNANDEZ
Journal:  Ann Otol Rhinol Laryngol       Date:  1961-03       Impact factor: 1.547

3.  [Ototoxicity of kanamycin studied day by day. Experimental electron microscopic study].

Authors:  J Darrouzet; A Guilhaume
Journal:  Rev Laryngol Otol Rhinol (Bord)       Date:  1974 Sep-Oct

4.  [Ototoxic effect of 3',4'-dideoxykanamycin B on the inner ear in the intrauterine guinea pigs (author's transl)].

Authors:  M Akiyoshi; K Sato; T Shoji; K Sugahiro; T Tajima
Journal:  Jpn J Antibiot       Date:  1974-12

5.  Correlative studies on the cochlear pathology and hearing loss in guinea-pigs after intoxication with ototoxic antibiotics.

Authors:  J Ylikoski
Journal:  Acta Otolaryngol Suppl       Date:  1974
  5 in total

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