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Literature DB >> 5260946

Deacylated tRNA-phe binding to a reticulocyte ribosomal site for the initiation of polyphenylalanine synthesis.

Abstract

The initiation of polyphenylalanine synthesis at low MgCl(2) concentration in the reticulocyte transfer system has been found to have a stringent requirement for deacylated tRNA(Phe). An initial poly-U-directed complex between deacylated tRNA(Phe) and ribosomes is formed. The onset of polyphenylalanine synthesis causes the rapid release of tRNA(Phe) from the complex. Thermal dissociation studies indicate that deacylated tRNA(Phe) and phenylalanyl-tRNA are bound to the same ribosomes. A total of three ribosomal tRNA binding sites is indicated.

Entities: Chemical Disease Gene

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Year: 1969 PMID： 5260946 PMCID： PMC223483 DOI： 10.1073/pnas.63.4.1431

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

16 in total

1. N-FORMYL-METHIONYL-S-RNA.

Authors: K MARCKER; F SANGER
Journal: J Mol Biol Date: 1964-06 Impact factor: 5.469

2. Transfer of amino acids from soluble ribonucleic aci to ribosome. III. Further studies on the interaction between ribosome and soluble ribonucleic aci.

Authors: M TAKANAMI
Journal: Biochim Biophys Acta Date: 1962-09-17

Deacylated tRNA-phe binding to a reticulocyte ribosomal site for the initiation of polyphenylalanine synthesis.

1. N-FORMYL-METHIONYL-S-RNA.

2. Transfer of amino acids from soluble ribonucleic aci to ribosome. III. Further studies on the interaction between ribosome and soluble ribonucleic aci.

3. Role of guanosine 5'-triphosphate in the initiation of Peptide synthesis, I. Synthesis of formylmethionyl-puromycin.

4. Deacylated transfer ribonucleic acid as a factor for peptide chain initiation in rabbit reticulocyte systems.

5. Involvement of transfer ribonucleic acid in early reactions of polyphenylalanine synthesis.

6. The requirement for tRNA for the shift in the optimum Mg++ concentration during the synthesis of polyphenylalanine.

7. The behaviour of acetylphenylalanyl soluble ribonucleic acid in polyphenylalanine synthesis.

8. A reaction associated with nonenzymatic binding in the reticulocyte transfer system.

9. Differential inactivation of soluble reticulocyte transfer factors with N-ethylmaleimide.

10. A proton exchange between purines and water and its application to biochemistry.

1. The binding sites for tRNA on eukaryotic ribosomes.