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Literature DB >> 5259761

Transformation and chromosome changes induced by Epstein-Barr virus in normal human leukocyte cultures.

Abstract

Three separate attempts to establish long-term leukocyte cultures from the peripheral blood of a healthy adult who had no evidence of previous infection with Epstein-Barr virus were consistently unsuccessful. On the other hand, in vitro infection of buffy-coat cells of this donor with Epstein-Barr virus resulted in blastoid transformation of the lymphocytes and long-term growth potential. The transformation was accompanied by major chromosome changes. The significance of these findings in relation to lymphoproliferative diseases in man remains to be determined.

Entities: Disease Species

Mesh：

Year: 1969 PMID： 5259761 PMCID： PMC223514 DOI： 10.1073/pnas.63.3.740

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

27 in total

1. Cloning of immunoglobulin-producing human leukemic and lymphoma cells in long-term cultures.

Authors: Y Hinuma; J T Grace
Journal: Proc Soc Exp Biol Med Date: 1967-01

2. Studies on leukocytes growing in continuous culture derived from normal human donors.

Authors: P Gerber; J H Monroe
Journal: J Natl Cancer Inst Date: 1968-04 Impact factor: 13.506

3. Culture of normal human leukocytes.

Authors: G E Moore; R E Gerner; H A Franklin
Journal: JAMA Date: 1967-02-20 Impact factor: 56.272

4. C-group chromosome marker in long-term leukocyte cultures.

Authors: G Kohn; V Diehl; W J Mellman; W Henle; G Henle
Journal: J Natl Cancer Inst Date: 1968-09 Impact factor: 13.506

5. Morphologic variations in human leukemic lymphoblasts (CCRF-CEM cells) after long-term culture and exposure to chemotherapeutic agents. A study with the electron microscope.

Authors: B G Uzman; G E Foley; S Farber; H Lazarus
Journal: Cancer Date: 1966-11 Impact factor: 6.860

6. Morphologic, cytogenetic and virologic studies in vitro of a malignant lymphoma from an African child.

Authors: A S Rabson; G T O'Conor; S Baron; J J Whang; F Y Legallais
Journal: Int J Cancer Date: 1966-01 Impact factor: 7.396

7. Burkitt lymphoma in New Guinea: establishment of a line of lymphoblasts in vitro and description of their fine structure.

Authors: J H Pope; B G Achong; M A Epstein; J Biddulph
Journal: J Natl Cancer Inst Date: 1967-11 Impact factor: 13.506

2. Heterogeneity of Epstein-Barr virus. III. Comparison of a transforming and a nontransforming virus by partial denaturation mapping of their DNAs.

Authors: H Delius; G W Bornkamm
Journal: J Virol Date: 1978-07 Impact factor: 5.103

3. DNA of Epstein-Barr virus. III. Identification of restriction enzyme fragments that contain DNA sequences which differ among strains of Epstein-Barr virus.

Authors: N Raab-Traub; R Pritchett; E Kieff
Journal: J Virol Date: 1978-08 Impact factor: 5.103

4. DNA of Epstein-Barr virus. IV. Linkage map of restriction enzyme fragments of the B95-8 and W91 strains of Epstein-Barr Virus.

Authors: D Given; E Kieff
Journal: J Virol Date: 1978-11 Impact factor: 5.103

8. Epstein-Barr virus-specific RNA. I. Analysis of viral RNA in cellular extracts and in the polyribosomal fraction of permissive and nonpermissive lymphoblastoid cell lines.

Authors: S D Hayward; E D Kieff
Journal: J Virol Date: 1976-05 Impact factor: 5.103

Review 9. Oncogenic properties of human viruses.

Authors: R Glaser; B Decker; F Rapp
Journal: In Vitro Date: 1975 May-Jun

10. Chemical mutagenesis at the phosphoribosyltransferase locus in cultured human lymphoblasts.

Authors: K Sato; R S Slesinski; J W Littlefield
Journal: Proc Natl Acad Sci U S A Date: 1972-05 Impact factor: 11.205

Transformation and chromosome changes induced by Epstein-Barr virus in normal human leukocyte cultures.

1. Cloning of immunoglobulin-producing human leukemic and lymphoma cells in long-term cultures.

2. Studies on leukocytes growing in continuous culture derived from normal human donors.

3. Culture of normal human leukocytes.

4. C-group chromosome marker in long-term leukocyte cultures.

5. Morphologic variations in human leukemic lymphoblasts (CCRF-CEM cells) after long-term culture and exposure to chemotherapeutic agents. A study with the electron microscope.

6. Morphologic, cytogenetic and virologic studies in vitro of a malignant lymphoma from an African child.

7. Burkitt lymphoma in New Guinea: establishment of a line of lymphoblasts in vitro and description of their fine structure.

8. Involvement of C group chromosomes in five Burkitt lymphoma cell lines.

9. Establishment of cell lines from peripheral leucocytes in infectious mononucleosis.

10. Herpes-type virus and chromosome marker in normal leukocytes after growth with irradiated Burkitt cells.

1. Infection of human and rhesus lymphoblastoid cells with Herpesvirus macaca.

2. Heterogeneity of Epstein-Barr virus. III. Comparison of a transforming and a nontransforming virus by partial denaturation mapping of their DNAs.

3. DNA of Epstein-Barr virus. III. Identification of restriction enzyme fragments that contain DNA sequences which differ among strains of Epstein-Barr virus.

4. DNA of Epstein-Barr virus. IV. Linkage map of restriction enzyme fragments of the B95-8 and W91 strains of Epstein-Barr Virus.

5. Epstein-Barr virus-specific RNA. III. Mapping of DNA encoding viral RNA in restringent infection.

6. Growth of B95-8 cells and expression of Epstein-Barr virus lytic phase in serum-free medium.

7. Proteins of Epstein-Barr virus. I. Analysis of the polypeptides of purified enveloped Epstein-Barr virus.

8. Epstein-Barr virus-specific RNA. I. Analysis of viral RNA in cellular extracts and in the polyribosomal fraction of permissive and nonpermissive lymphoblastoid cell lines.

Review 9. Oncogenic properties of human viruses.

10. Chemical mutagenesis at the phosphoribosyltransferase locus in cultured human lymphoblasts.