Literature DB >> 5257140

A muscarone-binding material in electroplax and its relation to the acetylcholine receptor. I. Centrifugal assay.

R D O'Brien, L P Gilmour.   

Abstract

A muscarone-binding material has been found in Torpedo electroplax. The material behaves in several ways as one would expect of the binding component of the acetylcholine receptor, especially in its high affinity for muscarone (approximate K = 7 x 10(-6)M), acetylcholine (approximate K = 1.1 x 10(-6)M), curare, and nicotine, and its insensitivity to noncholinergic agents; the reversibility of its muscarone binding; and its suitably small amount (about 1.8 nmole/gm). The material appears not to be acetylcholinesterase.

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Year:  1969        PMID： 5257140      PMCID： PMC223591          DOI： 10.1073/pnas.63.2.496

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  13 in total

1.  Acetylcholine-sensitive cells in the cerebral cortex.

Authors:  K KRNJEVIC; J W PHILLIS
Journal:  J Physiol       Date:  1963-04       Impact factor: 5.182

2.  Statistical estimations in enzyme kinetics.

Authors:  G N WILKINSON
Journal:  Biochem J       Date:  1961-08       Impact factor: 3.857

3.  [Structure dependence of the action of muscarine-like compounds].

Authors:  P WASER
Journal:  Experientia       Date:  1961-07-15

4.  Acetylcholinesterase inhibitory activities of muscarine and muscarone derivatives.

Authors:  B WITKOP; R C DURANT; S L FRIESS
Journal:  Experientia       Date:  1959-08-15

5.  Isolation and identification of the acetylcholine receptor protein of electric tissue.

Authors:  S EHRENPREIS
Journal:  Biochim Biophys Acta       Date:  1960-11-18

6.  [The structure and activity of muscarine, muscarone and their stereoisomers].

Authors:  P G WASER
Journal:  Experientia       Date:  1958-09-15

7.  Studies on the mechanis of curarization.

Authors:  C CHAGAS
Journal:  Ann N Y Acad Sci       Date:  1959-08-28       Impact factor: 5.691

8.  A study of the specificity of the complex formed by gallamine triethiodide with a macromolecular constituent of the electric organ.

Authors:  C CHAGAS; E PENNA-FRANCA; K NISHIE; E J GARCIA
Journal:  Arch Biochem Biophys       Date:  1958-05       Impact factor: 4.013

9.  On the contraction of muscle, chiefly in relation to the presence of "receptive" substances: Part I.

Authors:  J N Langley
Journal:  J Physiol       Date:  1907-12-31       Impact factor: 5.182

10.  Binding of dimethyl-C14-d-tubocurarine, methyl-C14-hexamethonium, and H3-alloferine by isolated synaptic membranes of brain cortex.

Authors:  J M Azcurra; E De Robertis
Journal:  Int J Neuropharmacol       Date:  1967-01
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  7 in total

1.  In vitro excitation of purified membrane fragments by cholinergic agonists : III. Comparison of the dose-response curves to decamethonium with the corresponding binding curves of decamethonium to the cholinergic receptor.

Authors:  M Kasai; J P Changeux
Journal:  J Membr Biol       Date:  1971-03       Impact factor: 1.843

Review 2.  Chemical events in conducting and synaptic membranes during electrical activity.

Authors:  D Nachmansohn
Journal:  Proc Natl Acad Sci U S A       Date:  1971-12       Impact factor: 11.205

3.  Use of a snake venom toxin to characterize the cholinergic receptor protein.

Authors:  J P Changeux; M Kasai; C Y Lee
Journal:  Proc Natl Acad Sci U S A       Date:  1970-11       Impact factor: 11.205

4.  A muscarone-binding material in electroplax and its relation to the acetylcholine receptor. II. Dialysis assay.

Authors:  R D O'Brien; L P Gilmour; M E Eldefrawi
Journal:  Proc Natl Acad Sci U S A       Date:  1970-02       Impact factor: 11.205

5.  Muscarinic cholinergic binding in rat brain.

Authors:  H I Yamamura; S H Snyder
Journal:  Proc Natl Acad Sci U S A       Date:  1974-05       Impact factor: 11.205

6.  Interactions of p-nitrobenzene diazonium fluoroborate and analogs with the active sites of acetylcholine-receptor and -esterase.

Authors:  H G Mautner; E Bartels
Journal:  Proc Natl Acad Sci U S A       Date:  1970-09       Impact factor: 11.205

7.  Binding sites for cholinergic ligands in a particulate fraction of Electrophorus electroplax.

Authors:  M E Eldefrawi; A T Eldefrawi; R D O'Brien
Journal:  Proc Natl Acad Sci U S A       Date:  1971-05       Impact factor: 11.205
  7 in total

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