Literature DB >> 5251696

Preliminary clinical assessment of I.C.R.F. 159 in acute leukaemia and lymphosarcoma.

K Hellmann, K A Newton, D N Whitmore, I W Hanham, J V Bond.   

Abstract

I.C.R.F. 159, a new antitumour agent, has been assessed in six patients with acute leukaemia and three with lymphosarcoma. In all but two there was a considerable fall in circulating primitive cells, and in one there was bone-marrow evidence of a partial remission. Severe toxic effects were seen in only one case; they consisted of alopecia and gastroenteritis. It is suggested that I.C.R.F. 159 is worth further examination in all forms of acute leukaemia and lymphosarcoma.

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Year:  1969        PMID: 5251696      PMCID: PMC1982474          DOI: 10.1136/bmj.1.5647.822

Source DB:  PubMed          Journal:  Br Med J        ISSN: 0007-1447


  15 in total

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2.  Effect of ICRF 159 on immune responses.

Authors:  K Hellmann
Journal:  Proc R Soc Med       Date:  1972-03

3.  Combined treatment of the Walker tumour with radiotherapy and ICRF 159.

Authors:  K Norpoth; A Schaphaus; H Ziegler; U Witting
Journal:  Z Krebsforsch Klin Onkol Cancer Res Clin Oncol       Date:  1974

4.  Drug-induced inhibition of tumour cell dissemination.

Authors:  K Burrage; K Hellmann; A J Salsbury
Journal:  Br J Pharmacol       Date:  1970-05       Impact factor: 8.739

5.  Inhibition of metastatic spread by I.C.R.F. 159: selective deletion of a malignant characteristic.

Authors:  A J Salsbury; K Burrage; K Hellmann
Journal:  Br Med J       Date:  1970-11-07

6.  Enhanced cerebrovascular permeability by Metrazol: significance for brain metastases.

Authors:  N Greig; K Hellmann
Journal:  Clin Exp Metastasis       Date:  1983 Jan-Mar       Impact factor: 5.150

7.  Topoisomerase II inhibition suppresses the proliferation of telomerase-negative cancers.

Authors:  Meng-Hsun Hsieh; Cheng-Hui Tsai; Chuan-Chuan Lin; Tsai-Kun Li; Ting-Wei Hung; Li-Te Chang; Ling-Wei Hsin; Shu-Chun Teng
Journal:  Cell Mol Life Sci       Date:  2014-11-28       Impact factor: 9.261

8.  Antitumor activity of MST-16, a novel derivative of bis(2,6-dioxopiperazine), in murine tumor models.

Authors:  T Narita; S Yaguchi; T Komatsu; M Takase; A Hoshino; M Inaba; S Tsukagoshi
Journal:  Cancer Chemother Pharmacol       Date:  1990       Impact factor: 3.333

9.  Reduction of chronic doxorubicin cardiotoxicity in beagle dogs by bis-morpholinomethyl derivative of razoxane (ICRF-159).

Authors:  E H Herman; V J Ferrans; H B Bhat; D T Witiak
Journal:  Cancer Chemother Pharmacol       Date:  1987       Impact factor: 3.333

10.  Antitumor activities and schedule dependence of orally administered MST-16, a novel derivative of bis(2,6-dioxopiperazine).

Authors:  T Narita; Y Koide; S Yaguchi; S Kimura; Y Izumisawa; M Takase; M Inaba; S Tsukagoshi
Journal:  Cancer Chemother Pharmacol       Date:  1991       Impact factor: 3.333

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