| Literature DB >> 5249272 |
P J Fialkow, R Lisker, J Detter, E R Giblett, C Zavala.
Abstract
In a study of 41 patients with chronic myelocytic leukemia, two were found to have the 6-phosphogluconate dehydrogenase heterozygous phenotype A-B, and two had the phenotype characteristic of Pd(B) homozygosity. Since one of the two with Pd(B) homozygosity was the mother of two children with the A phenotype, it was presumed that she carried a Pd(A) gene not expressed in her blood cells. his was confirmed by electrophoretic analysis of her fibroblasts, which had the A-B phenotypic pattern. Gene deletion is considered to be the most likely explanation.Entities:
Mesh：
Substances：
Year: 1969 PMID： 5249272 DOI： 10.1126/science.163.3863.194
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728