Literature DB >> 521450

[Comparative investigations on the organotropic carcinogenic effect of different N-nitroso compounds with rat after single and chronic treatment (author's transl)].

F Schweinsberg, M Kouros, K Manncke.   

Abstract

After the gavage of 200 mg N-nitrosodiethylamine per kg body weight only kidney tumors developed while long-term administration of 10 ppm N-nitrosodiethylamine induced esophageal tumors and hepatocellular carcinomas in female rats (SIV 50). This change of the organ-specific carcinogenic effect is not observed in experiments with N-methyl-N-nitrosobenzylamines substituted with a methyl group at the phenyl moiety. Both chronic treatment and single doses induced tumors of the esophagus and the pharynx.

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Year:  1979        PMID: 521450     DOI: 10.1007/BF00401006

Source DB:  PubMed          Journal:  J Cancer Res Clin Oncol        ISSN: 0171-5216            Impact factor:   4.553


  8 in total

1.  [ON THE MORPHOLOGY OF KIDNEY TUMORS IN RATS].

Authors:  C THOMAS; D SCHMAEHL
Journal:  Z Krebsforsch       Date:  1964-05-08

2.  [Organotropic carcinogenic effects of 65 various N-nitroso- compounds on BD rats].

Authors:  H Druckrey; R Preussmann; S Ivankovic; D Schmähl
Journal:  Z Krebsforsch       Date:  1967

3.  [Tumorinduction in mice with methylbenzylnitrosamine in low doses].

Authors:  J Sander; F Schweinsberg
Journal:  Z Krebsforsch Klin Onkol Cancer Res Clin Oncol       Date:  1973-05-07

4.  [Induction of malignant tumors in rats by simultaneous feeding of nitrite and secondary amines].

Authors:  J Sander; G Bürkle
Journal:  Z Krebsforsch       Date:  1969-09-25

5.  [Change of toxicity and carcinogenicity of N-methyl-N-nitrosobenzylamine in rats by methylsubstitution in the phenylresidue].

Authors:  F Schweinsberg; P Schott-Kollat; G Bürkle
Journal:  Z Krebsforsch Klin Onkol Cancer Res Clin Oncol       Date:  1977

6.  Autoradiography and organ distribution of N-methyl-N-nitro-sobenzylamine in rats.

Authors:  T Iizuka; S Ichmura; T Kawachi
Journal:  Gan       Date:  1978-08

7.  Induction of kidney tumours in the rat with dimethylnitrosamine (N-nitrosodimethylamine).

Authors:  P N MAGEE; J M BARNES
Journal:  J Pathol Bacteriol       Date:  1962-07

8.  The production of malignant primary hepatic tumours in the rat by feeding dimethylnitrosamine.

Authors:  P N MAGEE; J M BARNES
Journal:  Br J Cancer       Date:  1956-03       Impact factor: 7.640

  8 in total

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