Literature DB >> 520764

Conversion of 7-ketolithocholic acid to ursodeoxycholic acid by human intestinal anaerobic microorganisms: interchangeability of chenodeoxycholic acid and ursodeoxycholic acid.

S Higashi, T Setoguchi, T Katsuki.   

Abstract

Chenodeoxycholic acid, ursodeoxycholic acid and 7-ketolithocholic acid were incubated with human intestinal bacteria (source: 4 healthy males) at 37 degrees C for 72 hours in an anerobic condition. The bile acids of the products in culture medium were identified by three independent methods, thin layer chromatography, gas-liquid chromatography and GLC-mass spectrometry. Lithocholic acid, ursodeoxycholic acid and 7-ketolithocholic acid were observed in the culture of chenodeoxycholic acid. Lithocholic acid, chenodeoxycholic acid and 7-ketolithocholic acid were observed in the culture of ursodeoxycholic acid. Chenodeoxycholic acid and ursodeoxycholic acid were produced from 7-ketolithocholic acid. These data may suggest that chenodeoxycholic acid and ursodeoxycholic acid are interconvertible via 7-ketolithocholic acid by the mixed culture of human intestinal microorganisms under an anaerobic condition.

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Year:  1979        PMID： 520764     DOI： 10.1007/BF02773728

Source DB:  PubMed          Journal:  Gastroenterol Jpn        ISSN： 0435-1339


  10 in total

1.  Reversible enzymatic oxidation of bile acids.

Authors:  O HAYAISHI; Y SATO; W B JAKOBY; E F STOHLMAN
Journal:  Arch Biochem Biophys       Date:  1955-06       Impact factor: 4.013

2.  On the origin of lithocholic and ursodeoxycholic acids in man. Bile acids and steroids 106.

Authors:  K HELLSTROM; J SJOVALL
Journal:  Acta Physiol Scand       Date:  1961 Feb-Mar

3.  3-Hydroxy bile acid dehydrogenase from Escherichia freundii.

Authors:  O HAYAISHI; C SLAUGHTER; W B JAKOBY
Journal:  J Bacteriol       Date:  1960-01       Impact factor: 3.490

4.  Bile acids. VIII. Metabolism of 7-ketolithocholic acid-24-C14 in the rat.

Authors:  T A MAHOWALD; M W YIN; J T MATSCHINER; S L HSIA; E A DOISY; W H ELLIOTT; E A DOISY
Journal:  J Biol Chem       Date:  1958-02       Impact factor: 5.157

5.  Degradation of steroids by intestinal bacteria. II. Enzymes catalysing the oxidoreduction of the 3 alpha-, 7 alpha- and 12 alpha-hydroxyl groups in cholic acid, and the dehydroxylation of the 7-hydroxyl group.

Authors:  V Aries; M J Hill
Journal:  Biochim Biophys Acta       Date:  1970-05-05

6.  Cultivation of anaerobic intestinal bacteria.

Authors:  B S Drasar
Journal:  J Pathol Bacteriol       Date:  1967-10

7.  Anaerobic, bile acid transforming microorganisms in rat intestinal content.

Authors:  T Midtvedt; A Norman
Journal:  Acta Pathol Microbiol Scand       Date:  1968

8.  Bile acid transformations by microbial strains belonging to genera found in intestinal contents.

Authors:  T Midtvedt; A Norman
Journal:  Acta Pathol Microbiol Scand       Date:  1967

9.  Increased formation of ursodeoxycholic acid in patients treated with chenodeoxycholic acid.

Authors:  G Salen; G S Tint; B Eliav; N Deering; E H Mosbach
Journal:  J Clin Invest       Date:  1974-02       Impact factor: 14.808

10.  Isolated fecal microorganisms capable of 7-alpha-dehydroxylating bile acids.

Authors:  B E Gustafsson; T Midtvedt; A Norman
Journal:  J Exp Med       Date:  1966-02-01       Impact factor: 14.307
  10 in total
  1 in total

1.  High-dose ursodeoxycholic acid is associated with the development of colorectal neoplasia in patients with ulcerative colitis and primary sclerosing cholangitis.

Authors:  John E Eaton; Marina G Silveira; Darrell S Pardi; Emmanouil Sinakos; Kris V Kowdley; Velimir A C Luketic; M Edwyn Harrison; Timothy McCashland; Alex S Befeler; Denise Harnois; Roberta Jorgensen; Jan Petz; Keith D Lindor
Journal:  Am J Gastroenterol       Date:  2011-05-10       Impact factor: 10.864
  1 in total

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