Literature DB >> 52054

Potentiation of levodopa effect by intravenous L-prolyl-L-leucyl-glycine amide in man.

A Barbeau.   

Abstract

L-prolyl-L-leucyl-glycine amide (P.L.G.) has melanocyte-stimulating-hormone-inhibitory hormone (M.I.F.) activity. When injected intravenously as a bolus of 200 mg, it greatly potentiated the effect of an oral levodopa dose upon motor performance objectively measured by a battery of tests. This amelioration in motility was accompanied by improvement in intellectual functioning.

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Year:  1975        PMID： 52054     DOI： 10.1016/s0140-6736(75)90778-3

Source DB:  PubMed          Journal:  Lancet        ISSN： 0140-6736            Impact factor:   79.321


  10 in total

Review 1.  Concepts for biologically active peptides.

Authors:  Abba J Kastin; Weihong Pan
Journal:  Curr Pharm Des       Date:  2010-10       Impact factor: 3.116

2.  Failure of MIF-I to affect behavioral responses in patients with Parkinson's diseases under L-dopa therapy.

Authors:  T Caraceni; E A Parati; F Girotti; I Celano; C Frigerio; D Cocchi; E E Müller
Journal:  Psychopharmacology (Berl)       Date:  1979-06-21       Impact factor: 4.530

3.  Abnormal behavior after intracerebral injection of polypeptides from wheat gliadin: possible relevance to schizophrenia.

Authors:  F C Dohan; D R Levitt; L D Kushnir
Journal:  Pavlov J Biol Sci       Date:  1978 Apr-Jun

Review 4.  Levodopa and decarboxylase inhibitors: a review of their clinical pharmacology and use in the treatment of parkinsonism.

Authors:  R M Pinder; R N Brogden; P R Sawyer; T M Speight; G S Avery
Journal:  Drugs       Date:  1976       Impact factor: 9.546

5.  Effects of peptides on neurones in the substantia nigra and nucleus accumbens [proceedings].

Authors:  R D Pinnock; M J Turnbull; G N Woodruff
Journal:  Br J Pharmacol       Date:  1979-11       Impact factor: 8.739

6.  The pigmentary system of planaria. II. Physiology and functional morphology.

Authors:  G Palladini; L Medolago-Albani; V Margotta; A Conforti; A Carolei
Journal:  Cell Tissue Res       Date:  1979-06-27       Impact factor: 5.249

7.  Specific binding of photoaffinity-labeling peptidomimetics of Pro-Leu-Gly-NH2 to the dopamine D2L receptor: evidence for the allosteric modulation of the dopamine receptor.

Authors:  Amandeep Mann; Vaneeta Verma; Dipannita Basu; Kevin J Skoblenick; Michael G R Beyaert; Abigail Fisher; Nancy Thomas; Rodney L Johnson; Ram K Mishra
Journal:  Eur J Pharmacol       Date:  2010-05-27       Impact factor: 4.432

8.  Plasma beta-lipotropin levels in Parkinson's disease.

Authors:  M Wiesen; M D Yahr; D T Krieger
Journal:  J Neural Transm       Date:  1982       Impact factor: 3.575

9.  Mass spectrometric quantification of MIF-1 in mouse brain by multiple reaction monitoring.

Authors:  Indu Kheterpal; Abba J Kastin; Sahana Mollah; Chuanhui Yu; Hung Hsuchou; Weihong Pan
Journal:  Peptides       Date:  2009-04-11       Impact factor: 3.750

10.  Brain Activation by Peptide Pro-Leu-Gly-NH(2) (MIF-1).

Authors:  Reas S Khan; Chuanhui Yu; Abba J Kastin; Yi He; Rudolph H Ehrensing; Hung Hsuchou; Kirsten Prufer Stone; Weihong Pan
Journal:  Int J Pept       Date:  2010-03-28
  10 in total

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