Literature DB >> 520492

Elimination and metabolism of dimethylnitrosamine (DMN) by Xenopus laevis and other amphibians.

R R Rao, R H Clothier, R M Hodgson, M Balls.   

Abstract

The elimination of (14C)-DMN after i.p. injection into Xenopus was measured, as was the metabolism in vitro of (14C)-DMN by liver from Xenopus and 9 other amphibian species. In view of its rapid elimination from the body and low rate of metabolism by Xenopus liver in vitro, DMN is unlikely to be toxic or carcinogenic in Xenopus.

Entities:  

Mesh:

Substances:

Year:  1979        PMID: 520492     DOI: 10.1007/BF01953255

Source DB:  PubMed          Journal:  Experientia        ISSN: 0014-4754


  9 in total

1.  DIETHYLNITROSAMINE-INDUCED HEPATIC DEGENERATION AND NEOPLASIA IN THE AQUARIUM FISH, BRACHYDANIO RERIO.

Authors:  M F STANTON
Journal:  J Natl Cancer Inst       Date:  1965-01       Impact factor: 13.506

Review 2.  Formation and metabolism of alkylated nucleosides: possible role in carcinogenesis by nitroso compounds and alkylating agents.

Authors:  A E Pegg
Journal:  Adv Cancer Res       Date:  1977       Impact factor: 6.242

3.  Dimethylnitrosamine-induced hepatic cell carcinoma in rainbow trout.

Authors:  L M Ashley; J E Halver
Journal:  J Natl Cancer Inst       Date:  1968-08       Impact factor: 13.506

4.  Metabolism of dimethylnitrosamine by amphibians and fish in vitro.

Authors:  R Montesano; A J Ingram; P N Magee
Journal:  Experientia       Date:  1973-05-15

Review 5.  Nitroso compounds.

Authors:  P N Magee; P F Swann
Journal:  Br Med Bull       Date:  1969-09       Impact factor: 4.291

6.  The relationship between cell sizes, respiration rates and survival of amphibian tissues in long-term organ cultures.

Authors:  M A Monnickendam; M Balls
Journal:  Comp Biochem Physiol A Comp Physiol       Date:  1973-03-01

7.  The induction of tumors in Rana temporaria with nitrosamines.

Authors:  V V Khudoley
Journal:  Neoplasma       Date:  1977       Impact factor: 2.575

8.  The rate of breakdown of methyl methanesulphonate, dimethyl sulphate and N-methyl-N-nitrosourea in the rat.

Authors:  P F Swann
Journal:  Biochem J       Date:  1968-11       Impact factor: 3.857

9.  The lethal and hepatocarcinogenic effects of dimethylnitrosamine injection in the newt Triturus helveticus.

Authors:  A J Ingram
Journal:  Br J Cancer       Date:  1972-06       Impact factor: 7.640

  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.