Literature DB >> 51892

The immune response against an encephalitogenic fragment of guinea pig basic protein in the Lewis and Brown Norway strains or rat.

D E McFarlin, S C Hsu, S B Slemenda, C H Chou, R F Kibler.   

Abstract

Lewis rats which have Ir-EAE gene develop EAE after challenge with either GPBP or GPEF, a 42-residue fragment. BN rats which lack the Ir gene do not develop EAE after challenge with these proteins. The immune response against GPEF was compared in these two strains of rats. It was found that Le rats produce small amounts of antibody and a cell-mediated immune response against GPEF; in contrast BN rats did neither. These findings support the concept that the Ir-EAE gene exerts its effect by controlling the immune response against GPEF.

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Year:  1975        PMID： 51892

Source DB:  PubMed          Journal:  J Immunol        ISSN： 0022-1767            Impact factor:   5.422


  3 in total

1.  An IgG thymolytic autoantibody in rats which has specificity for a subpopulation of T cells.

Authors:  R J Perper; A L Oronsky; M Sanda
Journal:  Immunology       Date:  1976-12       Impact factor: 7.397

2.  Segregation of human peripheral blood lymphocytes according to their affinity for insolubilized histamine. Principal differences between males and females.

Authors:  B Tartakovsky; S Segal; A Shani; S Hellerstein; Y Weinstein; Z Bentwich
Journal:  Clin Exp Immunol       Date:  1979-10       Impact factor: 4.330

3.  Genetic resistance to the induction of experimental allergic encephalomyelitis in Lewis rats. I. Genetic analysis of an apparent mutant strain with phenotypic resistance to experimental allergic encephalomyelitis.

Authors:  F J Waxman; L E Perryman; D J Hinrichs; J E Coe
Journal:  J Exp Med       Date:  1981-01-01       Impact factor: 14.307
  3 in total

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