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Literature DB >> 518136

Studies with clonidine (dixarit) in menopausal women.

A E Schindler, D Müller, E Keller, R Göser, F Runkel.

Abstract

Eleven women with menopausal symptoms were treated with 150 micrograms Clonidine (dixarit) daily. Before and during therapy, plasma estradiol-17 beta, LH, FSH and prolactin levels were measured by specific radio-immunoassays. In addition, each patient recorded the number of hot flushes a day and symptoms were monitored by the Kupperman-index. A highly significant fall in the number of hot flushes by day and night occurred during therapy (p less than 0.001) and the Kupperman-index similarly improved. Significant pulse and blood pressure changes were not noted and plasma hormone concentrations remained unaltered. Medication was well tolerated. Clonidine therapy would appear to be the treatment of choice for menopausal symptoms if estrogens are contraindicated.

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Year: 1979 PMID： 518136 DOI： 10.1007/bf02109923

Source DB: PubMed Journal: Arch Gynecol ISSN： 0170-9925

21 in total

1. Correlation between climacteric symptoms and serum levels of estradiol, progesterone, follicle-stimulating hormone, and luteinizing hormone.

Authors: T Abe; N Furuhashi; Y Yamaya; Y Wada; A Hoshiai; M Suzuki
Journal: Am J Obstet Gynecol Date: 1977-09-01 Impact factor: 8.661

Studies with clonidine (dixarit) in menopausal women.

1. Correlation between climacteric symptoms and serum levels of estradiol, progesterone, follicle-stimulating hormone, and luteinizing hormone.

2. Failure of response of menopausal vasomotor symptoms to clonidine.

3. Menopausal flushing: double-blind trial of a non-hormonal medication.

4. A possible pharmacological approach to migraine.

5. [Reserpine therapy for menopausal trouble (author's transl)].

6. The effect of propranolol and oxazepam on some vegetative menopausal symptoms.

7. Clonidine in menopausal flushing: a double-blind trial.

8. The long-term management of migraine with clonidine.

9. Endocrine changes and symptomatology after oophorectomy in premenopausal women.

10. Vasomotor symptoms, serum estrogens, and gonadotropin levels in surgical menopause.

Review 1. Androgen deprivation therapy-associated vasomotor symptoms.

Review 2. Menopausal hot flashes: mechanisms, endocrinology, treatment.

Review 3. Hot flashes: a review of pathophysiology and treatment modalities.

4. Management of menopause-associated vasomotor symptoms: Current treatment options, challenges and future directions.