Literature DB >> 518111

Rectal aspirin--absorption and antipyretic effect.

K Connolly, L Lam, O C Ward.   

Abstract

Rectal acetylsalicylic acid was given to 14 children who had undergone open heart surgery. The effect on their temperatures was similar whether 15--30 or 30--50 mg/kg was given. Either dose was more effective than no treatment. The greatest fall in temperature occurred after 4 or 5 hours. Rectal aspirin in a triglyceride base is effective in lowering postoperative temperature. It should also be of use in treating other fevers. A dose of 20--25 mg/kg is suggested.

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Year:  1979        PMID： 518111      PMCID： PMC1545810          DOI： 10.1136/adc.54.9.713

Source DB:  PubMed          Journal:  Arch Dis Child        ISSN： 0003-9888            Impact factor:   3.791


  9 in total

1.  Bioavailability of aspirin from commercial suppositories.

Authors:  M Gibaldi; B Grundhofer
Journal:  J Pharm Sci       Date:  1975-06       Impact factor: 3.534

2.  The absorption of an n-methylated barbiturate and acetyl salicylic acid from different suppository masses.

Authors:  U SAMELIUS; A ASTROM
Journal:  Acta Pharmacol Toxicol (Copenh)       Date:  1958

3.  Bioavailability and tolerance studies on acetylsalicylic acid suppositories.

Authors:  K O Borg; G Ekenved; R Elofsson; J Sjögren; L Sölvell
Journal:  Acta Pharm Suec       Date:  1975

4.  Study of antipyretic therapy in current use.

Authors:  J Hunter
Journal:  Arch Dis Child       Date:  1973-04       Impact factor: 3.791

5.  Rectal absorption from aspirin suppositories in children and adults.

Authors:  M M Nowak; B Brundhofer; M Gibaldi
Journal:  Pediatrics       Date:  1974-07       Impact factor: 7.124

6.  Salicylate absorption from rectal suppositories.

Authors:  E L Parrott
Journal:  J Pharm Sci       Date:  1971-06       Impact factor: 3.534

7.  The acute rectal toxicity of acetylsalicylic acid.

Authors:  B B Coldwell; E M Boyd
Journal:  Can J Physiol Pharmacol       Date:  1966-11       Impact factor: 2.273

8.  Drug absorption from the rectum. 3. Asprin and some aspirin derivatives.

Authors:  W Lowenthal; J F Borzelleca; C D Corder
Journal:  J Pharm Sci       Date:  1970-09       Impact factor: 3.534

9.  Value of monitoring plasma salicylate levels in treating juvenile rheumatoid arthritis. Observations in 42 cases.

Authors:  M Bardare; G U Cislaghi; M Mandelli; F Sereni
Journal:  Arch Dis Child       Date:  1978-05       Impact factor: 3.791
  9 in total
  2 in total

1.  Correlation between dosage and antipyretic effect of aspirin in children.

Authors:  A Vigano; A Dalla Villa; I Cecchini; G C Biasini; N Principi
Journal:  Eur J Clin Pharmacol       Date:  1986       Impact factor: 2.953

2.  Gastro-duodenal injury associated with intake of 100-325 mg aspirin daily.

Authors:  R Oren; M Ligumsky; J Lysy; J Gonzales; J Zimmerman
Journal:  Postgrad Med J       Date:  1993-09       Impact factor: 2.401
  2 in total

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