Literature DB >> 517002

Isolation, structural organization and mechanism of action of mitochondrial steroid hydroxylating systems.

A A Akhrem, V N Lapko, A G Lapko, V M Shkumatov, V L Chashchin.   

Abstract

A scheme for the isolation of individual proteins of the 20S,22R-cholesterol hydroxylating system is presented. Physico-chemical and structural parameters of cytochrome P-450 are furnished. Self-reconstitution of indivudal proteins of the system into an enzyme unit is shown. Furthermore a regulation process of electron transport in the 20S,22R-cholesterol system is considered.

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Year:  1979        PMID： 517002

Source DB:  PubMed          Journal:  Acta Biol Med Ger        ISSN： 0001-5318


  5 in total

1.  Protein phosphorylation and intermolecular electron transfer: a joint experimental and computational study of a hormone biosynthesis pathway.

Authors:  Andy Zöllner; Melissa A Pasquinelli; Rita Bernhardt; David N Beratan
Journal:  J Am Chem Soc       Date:  2007-03-15       Impact factor: 15.419

2.  Expression of Cholesterol Hydroxylase/Lyase System Proteins in Yeast S. cerevisiae Cells as a Self-Processing Polyprotein.

Authors:  Vera S Efimova; Ludmila V Isaeva; Desislava S Makeeva; Mikhail A Rubtsov; Ludmila A Novikova
Journal:  Mol Biotechnol       Date:  2017-10       Impact factor: 2.695

3.  Analysis of In Vivo Activity of the Bovine Cholesterol Hydroxylase/Lyase System Proteins Expressed in Escherichia coli.

Authors:  V S Efimova; L V Isaeva; M A Rubtsov; L A Novikova
Journal:  Mol Biotechnol       Date:  2019-04       Impact factor: 2.695

4.  A pathway for the metabolism of vitamin D3: unique hydroxylated metabolites formed during catalysis with cytochrome P450scc (CYP11A1).

Authors:  O Guryev; R A Carvalho; S Usanov; A Gilep; R W Estabrook
Journal:  Proc Natl Acad Sci U S A       Date:  2003-12-01       Impact factor: 11.205

5.  Atomic Force Microscopy Study of Protein-Protein Interactions in the Cytochrome CYP11A1 (P450scc)-Containing Steroid Hydroxylase System.

Authors:  Y D Ivanov; P A Frantsuzov; A Zöllner; N V Medvedeva; A I Archakov; W Reinle; R Bernhardt
Journal:  Nanoscale Res Lett       Date:  2010-09-30       Impact factor: 4.703
  5 in total

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