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Literature DB >> 5169169

The toxicity of 125 IUdR in cultured mouse BP8 tumour cells.

Abstract

The toxicity of the low-energy electrons from (125)I in labelled IUdR was assayed by labelling the DNA of BP8 mouse tumour cells with the nucleoside and studying their subsequent growth in culture. Toxicity was observed in cells grown in medium containing more than 0·01 μCi/ml. The amount of label incorporated into cells showing deleterious effects is compared with that reported by others.

Entities: Chemical Disease Species

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Year: 1971 PMID： 5169169 PMCID： PMC2008760 DOI： 10.1038/bjc.1971.75

Source DB: PubMed Journal: Br J Cancer ISSN： 0007-0920 Impact factor: 7.640

2 in total

1. DEOXYRIBONUCLEIC ACID METABOLISM IN VIVO: I. CELL PROLIFERATION AND DEATH AS MEASURED BY INCORPORATION AND ELIMINATION OF IODODEOXYURIDINE.

Authors: W L HUGHES; S L COMMERFORD; D GITLIN; R C KRUEGER; B SCHULTZE; V SHAH; P REILLY
Journal: Fed Proc Date: 1964 May-Jun

2. Death and metastatic distribution of tumor cells in mice monitored with 125I-iododeoxy-uridine.

Authors: K G Hofer; W Prensky; W L Hughes
Journal: J Natl Cancer Inst Date: 1969-10 Impact factor: 13.506

2 in total

3 in total

The toxicity of 125 IUdR in cultured mouse BP8 tumour cells.

1. DEOXYRIBONUCLEIC ACID METABOLISM IN VIVO: I. CELL PROLIFERATION AND DEATH AS MEASURED BY INCORPORATION AND ELIMINATION OF IODODEOXYURIDINE.

2. Death and metastatic distribution of tumor cells in mice monitored with 125I-iododeoxy-uridine.

1. The use of 5-(125I)iodo-2'-deoxyuridine for monitoring DNA synthesis in organ culture.

2. 125IUDR labelling efficiency and cytotoxicity for murine tumours in vivo and in vitro.

3. Bystander effect produced by radiolabeled tumor cells in vivo.