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Literature DB >> 5167502

Analgesia from electrical stimulation in the brainstem of the rat.

D J Mayer, T L Wolfle, H Akil, B Carder, J C Liebeskind.

Abstract

Stimulation at several mesencephalic and diencephalic sites abolished responsiveness to intense pain in rats while leaving responsiveness to other sensory modes relatively unaffected. The peripheral field of analgesia was usually restricted to one-half or to one quadrant of the body, and painful stimuli applied outside this field elicited a normal reaction. Analgesia outlasted stimulation by up to 5 minutes. Most electrode placements that produced analgesia also supported self-stimulation. One placement supported self-stimulation only in the presence of pain.

Entities: Disease Species

Mesh：

Year: 1971 PMID： 5167502 DOI： 10.1126/science.174.4016.1351

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

84 in total

1. Descending inhibitory influences exerted by the brain stem upon the activities of dorsal horn lamina V cells induced by intra-arterial injection of bradykinin into the limbs.

Authors: J M Besson; G Guilbaud; D Le Bars
Journal: J Physiol Date: 1975-07 Impact factor: 5.182

2. Conditioned suppression of behavior maintained by intracranial stimulation as a function of stimulation intensity.

Authors: P J Russell
Journal: J Exp Anal Behav Date: 1975-03 Impact factor: 2.468

3. Joint manipulation reduces hyperalgesia by activation of monoamine receptors but not opioid or GABA receptors in the spinal cord.

Authors: D A Skyba; R Radhakrishnan; J J Rohlwing; A Wright; K A Sluka
Journal: Pain Date: 2003-11 Impact factor: 6.961

Analgesia from electrical stimulation in the brainstem of the rat.

1. Descending inhibitory influences exerted by the brain stem upon the activities of dorsal horn lamina V cells induced by intra-arterial injection of bradykinin into the limbs.

2. Conditioned suppression of behavior maintained by intracranial stimulation as a function of stimulation intensity.

3. Joint manipulation reduces hyperalgesia by activation of monoamine receptors but not opioid or GABA receptors in the spinal cord.

4. Tracheal occlusions evoke respiratory load compensation and neural activation in anesthetized rats.

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