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Literature DB >> 5167191

Synthesis and enzymic hydroxylation of protocollagen model peptide containing a hydroxyproline residue.

Abstract

1. Two protocollagen model peptides, Z-Gly-Pro-Hyp-Gly-(Pro-Pro-Gly)(5) (Z, benzyloxycarbonyl) and AOC-(Pro-Pro-Gly)(6) (AOC, tert.-pentyloxycarbonyl), were synthesized and hydroxylated with protocollagen proline hydroxylase. 2. The two model peptides were hydroxylated equally. The results suggest that the hydroxyl group of hydroxyproline contained in the N-terminal region of the peptide has no effect on the enzymic hydroxylation of the model peptide.

Entities: Chemical

Mesh：

Substances：

Year: 1971 PMID： 5167191 PMCID： PMC1177246 DOI： 10.1042/bj1240695

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

15 in total

1. Direct evidence for a correlation between amino acid sequence and cross striation pattern of collagen.

Authors: Klaus von der Mark; Peter Wendt; Friedrich Rexrodt; Klaus Kühn
Journal: FEBS Lett Date: 1970-11-18 Impact factor: 4.124

2. Peptides obtained by tryptic hydrolysis of performic acid-oxidized ribonuclease.

Authors: C H HIRS; S MOORE; W H STEIN
Journal: J Biol Chem Date: 1956-04 Impact factor: 5.157

3. A new reagent for detection of peptides, nucleotides, and other N-H-containing compounds on paper chromatograms.

Authors: R H MAZUR; B W ELLIS; P S CAMMARATA
Journal: J Biol Chem Date: 1962-05 Impact factor: 5.157

4. Modifications of a specific assay for hydroxyproline in urine.

Authors: K I Kivirikko; O Laitinen; D J Prockop
Journal: Anal Biochem Date: 1967-05 Impact factor: 3.365

5. Isolation and partial characterization of highly purified protocollagen proline hydroxylase.

Authors: J Halme; K I Kivirikko; K Simons
Journal: Biochim Biophys Acta Date: 1970-03-18

6. Use of anhydrous hydrogen fluoride in peptide synthesis. I. Behavior of various protective groups in anhydrous hydrogen fluoride.

Authors: S Sakakibara; Y Shimonishi; Y Kishida; M Okada; H Sugihara
Journal: Bull Chem Soc Jpn Date: 1967-09 Impact factor: 5.488

Synthesis and enzymic hydroxylation of protocollagen model peptide containing a hydroxyproline residue.

1. Direct evidence for a correlation between amino acid sequence and cross striation pattern of collagen.

2. Peptides obtained by tryptic hydrolysis of performic acid-oxidized ribonuclease.

3. A new reagent for detection of peptides, nucleotides, and other N-H-containing compounds on paper chromatograms.

4. Modifications of a specific assay for hydroxyproline in urine.

5. Isolation and partial characterization of highly purified protocollagen proline hydroxylase.

6. Use of anhydrous hydrogen fluoride in peptide synthesis. I. Behavior of various protective groups in anhydrous hydrogen fluoride.

7. Formation of enzyme-substrate complexes with protocollagen proline hydroxylase and large polypeptide substrates.

8. Hydroxylation of proline in synthetic polypeptides with purified protocollagen hydroxylase.

9. The trifluoroacetate method of peptide synthesis. II. An improved synthesis of bradykinin.

10. The enzymic hydroxylation of protocollagen models.

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