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Literature DB >> 5164952

A simulation study of brain compartments. Metabolism of glutamate and related substances in mouse brain.

Abstract

A computer model of the metabolism of glutamate, glutamine, gamma-aminobutyrate, and the tricarboxylic acid cycle in mouse brain has been constructed in terms of 39 reactions among 19 substances or groups of substances (permitting manipulation of 30 independent variables). The model is divided into two compartments, in conformity with previous models based on indirect evidence, and it is found that this compartmentation is indeed the same as that indicated directly with specifically (14)C-labelled acetate and glucose. The movement of materials between the large and small compartments has been studied; glutamine appears to flow from the small to the large compartment, gamma-aminobutyrate in the reverse direction.

Entities: Chemical Species

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Year: 1971 PMID： 5164952 PMCID： PMC1176925 DOI： 10.1042/bj1230211

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

21 in total

1. THE RELATIONSHIPS BETWEEN SUBSTRATES AND ENZYMES OF GLYCOLYSIS IN BRAIN.

Authors: O H LOWRY; J V PASSONNEAU
Journal: J Biol Chem Date: 1964-01 Impact factor: 5.157

2. EFFECT OF ISCHEMIA ON KNOWN SUBSTRATES AND COFACTORS OF THE GLYCOLYTIC PATHWAY IN BRAIN.

Authors: O H LOWRY; J V PASSONNEAU; F X HASSELBERGER; D W SCHULZ
Journal: J Biol Chem Date: 1964-01 Impact factor: 5.157

3. Intracellular localization of glutamate decarboxylase, gamma-aminobutyrate transaminase and some other enzymes in brain tissue.

Authors: G M van Kempen; C J van den Berg; H J van der Helm; H Veldstra
Journal: J Neurochem Date: 1965-07 Impact factor: 5.372

4. Subcellular distribution ot pyruvate carboxylase, diphosphopyridine nucleotide and triphosphopyridine nucleotide isocitrate dehydrogenases, and malate enzyme in rat brain.

Authors: L Salganicoff; R E Koeppe
Journal: J Biol Chem Date: 1968-06-25 Impact factor: 5.157

8. Measurements of the anaplerotic rate in the human cerebral cortex using 13C magnetic resonance spectroscopy and [1-13C] and [2-13C] glucose.

Authors: Graeme F Mason; Kitt Falk Petersen; Robin A de Graaf; Gerald I Shulman; Douglas L Rothman
Journal: J Neurochem Date: 2006-10-31 Impact factor: 5.372

9. Effective Mechanism for Synthesis of Neurotransmitter Glutamate and its Loading into Synaptic Vesicles.

Authors: Kouji Takeda; Tetsufumi Ueda
Journal: Neurochem Res Date: 2016-08-26 Impact factor: 3.996

Review 10. The anaplerotic flux and ammonia detoxification in hepatic encephalopathy.

Authors: Claudia Zwingmann
Journal: Metab Brain Dis Date: 2007-12 Impact factor: 3.584

A simulation study of brain compartments. Metabolism of glutamate and related substances in mouse brain.

1. THE RELATIONSHIPS BETWEEN SUBSTRATES AND ENZYMES OF GLYCOLYSIS IN BRAIN.

2. EFFECT OF ISCHEMIA ON KNOWN SUBSTRATES AND COFACTORS OF THE GLYCOLYTIC PATHWAY IN BRAIN.

3. Intracellular localization of glutamate decarboxylase, gamma-aminobutyrate transaminase and some other enzymes in brain tissue.

4. Subcellular distribution ot pyruvate carboxylase, diphosphopyridine nucleotide and triphosphopyridine nucleotide isocitrate dehydrogenases, and malate enzyme in rat brain.

5. Contribution of the GABA bypath to glucose oxidation, and the development of compartmentation in the brain.

6. On the contribution of the tricarboxylic acid cycle to the synthesis of glutamate, glutamine and aspartate in brain.

7. Effects of changes in brain metabolism on the levels of citric acid cycle intermediates.

8. Precursors in vivo of glutamate, aspartate and their derivatives of rat brain.

9. Utilization in vivo of glucose and volatile fatty acids by sheep brain for the synthesis of acidic amino acids.

10. RATE OF UTILIZATION OF GLUCOSE AND 'COMPARTMENTATION' OF ALPHA-OXOGLUTARATE AND GLUTAMATE IN RAT BRAIN.

1. Hypo-osmotic swelling modifies glutamate-glutamine cycle in the cerebral cortex and in astrocyte cultures.

Review 2. Role of astrocytes in brain function and disease.

Review 3. Astrocytic regulation of glutamate homeostasis in epilepsy.

Review 4. The micro-architecture of the cerebral cortex: functional neuroimaging models and metabolism.

5. Rates of exchange of free amino acids between plasma and brain in mice.

Review 6. Interpreting functional imaging studies in terms of neurotransmitter cycling.

7. Changes in glutamate-cycle enzyme mRNA levels in a rat model of hepatic encephalopathy.

8. Measurements of the anaplerotic rate in the human cerebral cortex using 13C magnetic resonance spectroscopy and [1-13C] and [2-13C] glucose.

9. Effective Mechanism for Synthesis of Neurotransmitter Glutamate and its Loading into Synaptic Vesicles.

Review 10. The anaplerotic flux and ammonia detoxification in hepatic encephalopathy.