Literature DB >> 5157729

Blocking effect of McN-A-343 on cardiac slowing produced by vagal stimulation.

S Chiba, K Hashimoto, K Kubota, S Sato.   

Abstract

The effect of McN-A-343 was studied by direct administration into the sinus node artery of dogs vagotomized at the mid-cervical level. McN-A-343 blocked sinus bradycardia caused by electrical stimulation of the right vagus, while bradycardia induced by administration of acetylcholine or nicotine into the sinus node artery was not modified.

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Year:  1971        PMID： 5157729      PMCID： PMC1665803          DOI： 10.1111/j.1476-5381.1971.tb07198.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  7 in total

1.  Chronic extrinsic cardiac denervation by regional neural ablation. Description of the operation, verification of the denervation, and its effects on myocardial catecholamines.

Authors:  T COOPER; J W GILBERT; R D BLOODWELL; J R CROUT
Journal:  Circ Res       Date:  1961-03       Impact factor: 17.367

2.  An unusual type of sympathetic ganglionic stimulant.

Authors:  A P ROSZKOWSKI
Journal:  J Pharmacol Exp Ther       Date:  1961-05       Impact factor: 4.030

3.  Responses of the sino-atrial node to change in pressure in the sinus node artery.

Authors:  K Hashimoto; S Tanaka; M Hirata; S Chiba
Journal:  Circ Res       Date:  1967-09       Impact factor: 17.367

4.  Pharmacologic isolation of sinoatrial activity from effects of neural excitation by use of tetrodotoxin.

Authors:  K Hashimoto; S Chiba
Journal:  J Pharmacol Exp Ther       Date:  1969-11       Impact factor: 4.030

5.  Effects of nicotine and dimethylphenylpiperazinium on the S-A node activity of dogs in situ.

Authors:  S Chiba; S Sato; K Hashimoto
Journal:  Tohoku J Exp Med       Date:  1969-12       Impact factor: 1.848

6.  The actions of McN-A-343, pilocarpine and acetyl-beta-methylcholine on sympathetic ganglion cells of the frog.

Authors:  B L Ginsborg
Journal:  J Pharmacol Exp Ther       Date:  1965-11       Impact factor: 4.030

7.  Excitation of the parasympathetic ganglia of the canine urinary bladder through a muscarinic mechanism.

Authors:  N Taira; S Matsumura; K Hashimoto
Journal:  J Pharmacol Exp Ther       Date:  1971-01       Impact factor: 4.030
  7 in total
  1 in total

1.  Effects of the muscarinic agonist McN-A-343 on the release by sympathetic nerve stimulation of (3H)-noradrenaline from rabbit isolated ear arteries and guinea-pig atria.

Authors:  G S Allen; M J Rand; D F Story
Journal:  Br J Pharmacol       Date:  1974-05       Impact factor: 8.739
  1 in total

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