| Literature DB >> 5152034 |
Abstract
The renal clearance of inulin (ClIN) was measured in anaesthetized male rats using a continuous intravenous infusion method.ClIN was independent of urine flow rate provided this was greater than 0.03 ml/minute.At flow rates lower than this, CIIN was reduced and appeared to correlate with the rate of flow.In experiments where a constant kidney function is required. e.g., pharmacokinetic studies, it is advisable to maintain urine, flow rates in the rat above 0.03 ml/minute.Entities:
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Year: 1971 PMID： 5152034 PMCID： PMC1665727 DOI： 10.1111/j.1476-5381.1971.tb07226.x
Source DB: PubMed Journal: Br J Pharmacol ISSN： 0007-1188 Impact factor: 8.739