Literature DB >> 514938

Left ventricular failure with labetalol.

M A Frais, T J Bayley.   

Abstract

A patient treated for hypertension with labetalol developed left ventricular failure. When the drug was withdrawn and the BP controlled with 2 other agents, the signs of heart failure regressed. The ill effects in this case could have been because the beta-blocking effects of labetalol are 4 to 6 times greater than the alpha-blocking effects. Caution should be exercised when prescribing this drug for patients with heart failure or with previous symptoms.

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Year:  1979        PMID： 514938      PMCID： PMC2428082          DOI： 10.1136/pgmj.55.646.567

Source DB:  PubMed          Journal:  Postgrad Med J        ISSN： 0032-5473            Impact factor:   2.401


  4 in total

1.  The effects of oral AH 5158, a combined α and β-adrenoceptor antagonist, in healthy volunteers.

Authors:  D A Richards; E P Woodings; M D Stephens; J G Maconochie
Journal:  Br J Clin Pharmacol       Date:  1974-12       Impact factor: 4.335

2.  Pressor response after intravenous labetalol.

Authors:  M Crofton; R Gabriel
Journal:  Br Med J       Date:  1977-09-17

Review 3.  A review of the animal pharmacology of labetalol, a combined alpha- and beta-adrenoceptor-blocking drug.

Authors:  R T Brittain; G P Levy
Journal:  Br J Clin Pharmacol       Date:  1976-08       Impact factor: 4.335

4.  Haemodynamic effects of long-term oral labetalol.

Authors:  R C Edwards; E B Raftery
Journal:  Br J Clin Pharmacol       Date:  1976-08       Impact factor: 4.335
  4 in total
  1 in total

Review 1.  Combined alpha- and beta-receptor inhibition in the treatment of hypertension.

Authors:  B N Prichard
Journal:  Drugs       Date:  1984       Impact factor: 9.546
  1 in total

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