Literature DB >> 5144225

Effect of alpha-amanitin on ribonucleic acid polymerase II of rat brain nuclei and on retention of avoidance conditioning.

N Montanaro, F Novello, F Stirpe.   

Abstract

1. alpha-Amanitin inhibits in vitro the activity of RNA polymerase II of rat brain nuclei. 2. The toxin does not pass the blood-brain barrier, but when injected intracerebrally is highly toxic for rats, and causes inhibition of RNA polymerase II of isolated brain nuclei. 3. Intracerebral injection of alpha-amanitin 6h before training to a passive avoidance task is followed by impaired performance of rats on retesting after 7 days, without affecting performance on retesting immediately after training.

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Year:  1971        PMID： 5144225      PMCID： PMC1178273          DOI： 10.1042/bj1251087

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  13 in total

1.  Simultaneous assay of RNA polymerase I and II in nuclei isolated from resting and growing rat liver with the use of alpha-amanitin.

Authors:  F Novello; F Stirpe
Journal:  FEBS Lett       Date:  1970-05-11       Impact factor: 4.124

2.  Isolation of pure and unaltered liver nuclei morphology and biochemical composition.

Authors:  J CHAUVEAU; Y MOULE; C ROUILLER
Journal:  Exp Cell Res       Date:  1956-08       Impact factor: 3.905

3.  A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid.

Authors:  K BURTON
Journal:  Biochem J       Date:  1956-02       Impact factor: 3.857

4.  Alpha-amanitin: a specific inhibitor of one of two DNA-pendent RNA polymerase activities from calf thymus.

Authors:  C Kedinger; M Gniazdowski; J L Mandel; F Gissinger; P Chambon
Journal:  Biochem Biophys Res Commun       Date:  1970-01-06       Impact factor: 3.575

Review 5.  The biochemistry of learning: an evaluation of the role of RNA and protein.

Authors:  E Glassman
Journal:  Annu Rev Biochem       Date:  1969       Impact factor: 23.643

6.  Multiple forms of DNA-dependent RNA polymerase in eukaryotic organisms.

Authors:  R G Roeder; W J Rutter
Journal:  Nature       Date:  1969-10-18       Impact factor: 49.962

7.  Different responses of soluble whole nuclear RNA polymerase and soluble nucleolar RNA polymerase to divalent cations and to inhibition by alpha-amanitin.

Authors:  S T Jacob; E M Sajdel; H N Munro
Journal:  Biochem Biophys Res Commun       Date:  1970-02-20       Impact factor: 3.575

8.  A simple and rapid method for injecting H3-norepinephrine into the lateral ventricle of the rat brain.

Authors:  E P Noble; R J Wurtman; J Axelrod
Journal:  Life Sci       Date:  1967-02-01       Impact factor: 5.037

9.  Studies on ribonucleic acid and homopolyribonucleotide formation in neuronal, glial and liver nuclei.

Authors:  T Kato; M Kurokawa
Journal:  Biochem J       Date:  1970-02       Impact factor: 3.857

10.  Studies on the pathogenesis of liver necrosis by alpha-amanitin. Effect of alpha-amanitin on ribonucleic acid synthesis and on ribonucleic acid polymerase in mouse liver nuclei.

Authors:  F Stirpe; L Fiume
Journal:  Biochem J       Date:  1967-11       Impact factor: 3.857
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  2 in total

1.  Effect of a brain-specific protein (S-100 protein) on the nucleolar RNA polymerase activity in isolated brain nuclei.

Authors:  N Miani; F Michetti; G De Renzis; A Caniglia
Journal:  Experientia       Date:  1973-12

2.  [Structure and mode of action of the amatoxins].

Authors:  T Wieland
Journal:  Naturwissenschaften       Date:  1972-06
  2 in total

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