Literature DB >> 514118

Is idiopathic dementia a regional vitamin deficiency state?

R Spector, P Cancilla, A Damasio.   

Abstract

We hypothesize that some cases of idiopathic dementia are due to a gradual undernourishment of the brain with water-soluble vitamins. This occurs because the choroid plexus and possibly other transport loci in the central nervous system become unable to transport water-soluble vitamins from blood into the central nervous system in adequate amounts. If this testable hypothesis is correct, direct injections of vitamins into the ventricular cerebrospinal fluid should ameliorate the development of dementia.

Entities:  

Mesh:

Substances:

Year:  1979        PMID: 514118     DOI: 10.1016/0306-9877(79)90038-0

Source DB:  PubMed          Journal:  Med Hypotheses        ISSN: 0306-9877            Impact factor:   1.538


  3 in total

1.  Cobalamin deficiency, hyperhomocysteinemia, and dementia.

Authors:  Steven F Werder
Journal:  Neuropsychiatr Dis Treat       Date:  2010-05-06       Impact factor: 2.570

2.  Choroid plexus failure in the Kearns-Sayre syndrome.

Authors:  Reynold Spector; Conrad E Johanson
Journal:  Cerebrospinal Fluid Res       Date:  2010-08-23

3.  Sustained choroid plexus function in human elderly and Alzheimer's disease patients.

Authors:  Reynold Spector; Conrad E Johanson
Journal:  Fluids Barriers CNS       Date:  2013-09-24
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.