| Literature DB >> 5135720 |
M C Archer, S D Clark, J E Thilly, S R Tannenbaum.
Abstract
Creatine reacts with nitrite under acid conditions to produce first sarcosine and then N-nitrososarcosine, which is a weak carcinogen in the rat. Creatinine reacts with acidified nitrite to produce either creatinine-5-oxime or 1-methylhydantoin-5-oxime, depending on reaction conditions. The toxicity and environmental significance of these compounds is not yet known.Entities:
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Year: 1971 PMID： 5135720 DOI： 10.1126/science.174.4016.1341
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728