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Literature DB >> 5128664

Phosphoenolpyruvate carboxykinase of kidney. Subcellular distribution and response to acid-base changes.

Abstract

1. A method for the assay of phosphoenolpyruvate carboxykinase is presented, based on the enzymic determination of the phosphoenolpyruvate produced by the enzyme reaction. 2. The subcellular distribution of phosphoenolpyruvate carboxykinase in the kidney of several animal species resembled the distribution in the liver. 3. The rise in enzyme activity in the kidney cortex of rats made acidotic by feeding with ammonium chloride was not prevented by administration of ethionine or actinomycin. 4. The possibility is suggested that in the kidney acidosis causes activation of an inactive form of the enzyme already present.

Entities: Chemical Disease Species

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Year: 1971 PMID： 5128664 PMCID： PMC1176897 DOI： 10.1042/bj1230035

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

12 in total

1. Protein measurement with the Folin phenol reagent.

Authors: O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal: J Biol Chem Date: 1951-11 Impact factor: 5.157

2. Purification of phosphoenolpyruvate carboxykinase from the cytosol fraction of rat liver and the immunochemical demonstration of differences between this enzyme and the mitochondrial phosphoenolpyruvate carboxykinase.

Authors: F J Ballard; R W Hanson
Journal: J Biol Chem Date: 1969-10-25 Impact factor: 5.157

3. Concentrations of metabolic intermediates in kidneys of rats with metabolic acidosis.

Authors: G A Alleyne
Journal: Nature Date: 1968-03-02 Impact factor: 49.962

4. Renal gluconeogenesis in acidosis, alkalosis, and potassium deficiency: its possible role in regulation of renal ammonia production.

Authors: A D Goodman; R E Fuisz; G F Cahill
Journal: J Clin Invest Date: 1966-04 Impact factor: 14.808

5. Relation of renal gluconeogenesis to ammonia production in the dog and rat.

Authors: W E Goorno; F C Rector; D W Seldin
Journal: Am J Physiol Date: 1967-10

6. On the mechanism of gluconeogenesis and its regulation. II. The mechanism of gluconeogenesis from pyruvate and fumarate.

Authors: W Seubert; W Huth
Journal: Biochem Z Date: 1965-11-15

7. Acid-base alterations and renal gluconeogenesis: effect of pH, bicarbonate concentration, and PCO2.

Authors: D E Kamm; R E Fuisz; A D Goodman; G F Cahill
Journal: J Clin Invest Date: 1967-07 Impact factor: 14.808

8. Renal metabolic response to acid-base changes. II. The early effects of metabolic acidosis on renal metabolism in the rat.

Authors: G A Alleyne
Journal: J Clin Invest Date: 1970-05 Impact factor: 14.808

9. Renal metabolic response to acid base changes. I. Enzymatic control of ammoniagenesis in the rat.

Authors: G A Alleyne; G H Scullard
Journal: J Clin Invest Date: 1969-02 Impact factor: 14.808

10. The regulation of phosphoenolpyruvate synthesis in pigeon liver.

Authors: W Gevers
Journal: Biochem J Date: 1967-04 Impact factor: 3.857

10 in total

1. Tissue-specific, developmental, hormonal, and dietary regulation of rat phosphoenolpyruvate carboxykinase-human growth hormone fusion genes in transgenic mice.

Authors: M K Short; D E Clouthier; I M Schaefer; R E Hammer; M A Magnuson; E G Beale
Journal: Mol Cell Biol Date: 1992-03 Impact factor: 4.272

2. Effects of the diuretics furosemide, ethacrynic acid, and chlorothiazide on gluconeogenesis from various substrates in rat kidney cortex slices.

Authors: G Fülgraff; H Nünemann; D Sudhoff
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1972 Impact factor: 3.000

3. Regulation of renal gluconeogenesis by calcium ions, hormones and adenosine 3':5'-cyclic monophosphate.

Authors: A Roobol; G A Alleyne
Journal: Biochem J Date: 1973-05 Impact factor: 3.857

4. The activity of phosphoenolpyruvate carboxykinase in rat tissues. Assay techniques and effects of dietary and hormonal changes.

Authors: C I Pogson; S A Smith
Journal: Biochem J Date: 1975-11 Impact factor: 3.857

5. The effect of steroids and ammonium chloride acidosis on phosphoenolpyruvate carboxykinase in rat kidney cortex. II. The kinetics of enzyme induction.

Authors: I D Longshaw; G A Alleyne; C I Pogson
Journal: J Clin Invest Date: 1972-09 Impact factor: 14.808

6. The interrelationship of the concentration of hydrogen ions, bicarbonate ions, carbon dioxide and calcium ions in the regulation of renal gluconeogenesis in the rat.

Authors: G A Alleyne; H Flores; A Roobol
Journal: Biochem J Date: 1973-11 Impact factor: 3.857

7. The effect of steroids and ammonium chloride acidosis on phosphoenolpyruvate carboxykinase in rat kidney cortex. I. Differentiation of the inductive process and characterization of enzyme activities.

Authors: I D Longshaw; C I Pogson
Journal: J Clin Invest Date: 1972-09 Impact factor: 14.808